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PMID: 22096659 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Review

The emergence of lncRNAs in cancer biology.

Cancer discovery ·Vol. 1 ·No. 5 ·2011-10-00 ·Pages 391-407

Prensner JR, Chinnaiyan AM

Abstract

The discovery of numerous noncoding RNA (ncRNA) transcripts in species from yeast to mammals has dramatically altered our understanding of cell biology, especially the biology of diseases such as cancer. In humans, the identification of abundant long ncRNA (lncRNA) >200 bp has catalyzed their characterization as critical components of cancer biology. Recently, roles for lncRNAs as drivers of tumor suppressive and oncogenic functions have appeared in prevalent cancer types, such as breast and prostate cancer. In this review, we highlight the emerging impact of ncRNAs in cancer research, with a particular focus on the mechanisms and functions of lncRNAs.

Keywords
cancer epigenetics lncRNA long noncoding RNA
MeSH Terms
Humans Neoplasms/genetics RNA, Untranslated/genetics
Chemicals
RNA, Untranslated
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Prensner John R
Michigan Center for Translational Pathology, Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Chinnaiyan Arul M
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Article Info
Journal
Cancer discovery
Abbr.
Cancer Discov
ISSN
2159-8290
DOI
10.1158/2159-8290.CD-11-0209
Published
2011-10-00
Pages
391-407
Language
English
Region
United States
NLM ID
101561693
PMCID
PMC3215093
Subset
IM
Grants
NCI NIH HHS · U01 CA111275-05 · United States
Howard Hughes Medical Institute · United States
NCI NIH HHS · U01 CA 11275 · United States
NCI NIH HHS · P50CA69568 · United States
NCI NIH HHS · P50 CA069568 · United States
NCI NIH HHS · U01 CA111275 · United States
NCI NIH HHS · P50 CA069568-10 · United States
External Links
PubMed source DOI: 10.1158/2159-8290.CD-11-0209 PMC Full Text View journal details
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