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PMID: 22076556 Published · epublish English Journal Article Research Support, Non-U.S. Gov't Review

Towards a systems understanding of MHC class I and MHC class II antigen presentation.

Nature reviews. Immunology ·Vol. 11 ·No. 12 ·2011-11-11 ·Pages 823-36

Neefjes J, Jongsma ML, Paul P, Bakke O

Abstract

The molecular details of antigen processing and presentation by MHC class I and class II molecules have been studied extensively for almost three decades. Although the basic principles of these processes were laid out approximately 10 years ago, the recent years have revealed many details and provided new insights into their control and specificity. MHC molecules use various biochemical reactions to achieve successful presentation of antigenic fragments to the immune system. Here we present a timely evaluation of the biology of antigen presentation and a survey of issues that are considered unresolved. The continuing flow of new details into our understanding of the biology of MHC class I and class II antigen presentation builds a system involving several cell biological processes, which is discussed in this Review.

MeSH Terms
Animals Antigen Presentation/genetics,immunology Biological Transport Dendritic Cells/immunology Endoplasmic Reticulum/metabolism Genes, MHC Class I Genes, MHC Class II Histocompatibility Antigens Class I/immunology Histocompatibility Antigens Class II/immunology Humans Mice Models, Immunological Multiprotein Complexes/immunology Peptide Fragments/immunology Polymorphism, Genetic Proteasome Endopeptidase Complex/metabolism RNA, Small Interfering/genetics,immunology Structure-Activity Relationship Systems Theory
Chemicals
Histocompatibility Antigens Class I Histocompatibility Antigens Class II Multiprotein Complexes Peptide Fragments RNA, Small Interfering Proteasome Endopeptidase Complex
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Neefjes Jacques
Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands. j.neefjes@nki.nl
Jongsma Marlieke L M
Paul Petra
Bakke Oddmund
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Article Info
Journal
Nature reviews. Immunology
Abbr.
Nat Rev Immunol
ISSN
1474-1741
DOI
10.1038/nri3084
Email
j.neefjes@nki.nl
Published
2011-11-11
Epub
2011-00-11
Pages
823-36
Language
English
Region
England
NLM ID
101124169
Subset
IM
External Links
PubMed source DOI: 10.1038/nri3084 View journal details
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