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PMID: 21978762 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

K11-linked ubiquitin chains as novel regulators of cell division.

Trends in cell biology ·Vol. 21 ·No. 11 ·2011-11-00 ·Pages 656-63

Wickliffe KE, Williamson A, Meyer HJ, Kelly A, Rape M

Abstract

Modification of proteins with ubiquitin chains is an essential regulatory event in cell cycle control. Differences in the connectivity of ubiquitin chains are believed to result in distinct functional consequences for the modified proteins. Among eight possible homogenous chain types, canonical Lys48-linked ubiquitin chains have long been recognized to drive the proteasomal degradation of cell cycle regulators, and Lys48 is the only essential lysine residue of ubiquitin in yeast. It thus came as a surprise that in higher eukaryotes atypical K11-linked ubiquitin chains regulate the substrates of the anaphase-promoting complex and control progression through mitosis. We discuss recent findings that shed light on the assembly and function of K11-linked chains during cell division.

MeSH Terms
Anaphase-Promoting Complex-Cyclosome Animals Cell Division Humans Polyubiquitin/physiology Protein Multimerization Ubiquitin-Protein Ligase Complexes/metabolism Ubiquitinated Proteins/metabolism Ubiquitination
Chemicals
Ubiquitinated Proteins Polyubiquitin Ubiquitin-Protein Ligase Complexes Anaphase-Promoting Complex-Cyclosome
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Wickliffe Katherine E
Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, USA.
Williamson Adam
Meyer Hermann-Josef
Kelly Aileen
Rape Michael
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Article Info
Journal
Trends in cell biology
Abbr.
Trends Cell Biol
ISSN
1879-3088
DOI
10.1016/j.tcb.2011.08.008
Published
2011-11-00
Epub
2011-00-04
Pages
656-63
Language
English
Region
England
NLM ID
9200566
PMCID
PMC3205209
Subset
IM
Grants
NIH HHS · DP2 OD003088 · United States
NIGMS NIH HHS · T32 GM007232 · United States
NIGMS NIH HHS · R01 GM083064 · United States
NIH HHS · DP2 OD003088-01 · United States
NIGMS NIH HHS · R01 GM083064-04 · United States
External Links
PubMed source DOI: 10.1016/j.tcb.2011.08.008 PMC Full Text View journal details
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