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PMID: 2196836 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

The parvalbumin-containing nonpyramidal neurons in the rat hippocampus.

Anatomy and embryology ·Vol. 181 ·No. 5 ·1990-00-00 ·Pages 413-25

Nitsch R, Soriano E, Frotscher M

Abstract

The calcium-binding protein parvalbumin is considered to be involved in the control of intracellular ion homeostasis of highly active inhibitory neurons. A review of the light and electron microscopical features as well as the identified synaptic connections of these neurons is presented. Parvalbumin-containing neurons are mostly located within or in the vicinity of the granule or pyramidal cell layer. They form a subgroup of GABAergic neurons that has a target specificity for the cell body region. Their fine structural characteristics are identical to those known for hippocampal inhibitory neurons. Parvalbumin-containing neurons are involved in several inhibitory pathways: feed-back inhibition, feed-forward inhibition and disinhibition. The functional implications of our own as well as published data are discussed. Special consideration is given to the possible physiological role of parvalbumin in these neurons.

MeSH Terms
Animals Hippocampus/metabolism Muscle Proteins/biosynthesis Neurons/ultrastructure Parvalbumins/biosynthesis,physiology Rats
Chemicals
Muscle Proteins Parvalbumins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Nitsch R
Institute of Anatomy, University of Freiburg, Federal Republic of Germany.
Soriano E
Frotscher M
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Article Info
Journal
Anatomy and embryology
Abbr.
Anat Embryol (Berl)
ISSN
0340-2061
DOI
10.1007/BF02433788
Published
1990-00-00
Pages
413-25
Language
English
Region
Germany
NLM ID
7505194
Subset
IM
External Links
PubMed source DOI: 10.1007/BF02433788
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