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PMID: 2721621 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Mossy fiber synapses on glutamate decarboxylase-immunoreactive neurons: evidence for feed-forward inhibition in the CA3 region of the hippocampus.

Experimental brain research ·Vol. 75 ·No. 2 ·1989-00-00 ·Pages 441-5

Frotscher M

Abstract

Mossy fibers are known to form excitatory synapses on pyramidal neurons in regio inferior of the hippocampus. This study demonstrates that the mossy fibers also establish synaptic contacts with glutamate decarboxylase-immunoreactive, supposedly GABAergic inhibitory neurons in the CA3 region. The observed connection provides a morphological basis for feed-forward inhibition of the pyramidal cells.

MeSH Terms
Animals Glutamate Decarboxylase/metabolism Hippocampus/metabolism,ultrastructure Male Rats Rats, Inbred Strains Synapses/ultrastructure gamma-Aminobutyric Acid/metabolism
Chemicals
gamma-Aminobutyric Acid Glutamate Decarboxylase
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Frotscher M
Institute of Anatomy, Johann Wolfgang Goethe University, Frankfurt am Main, Federal Republic of Germany.
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22 references, click to expand
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Article Info
Journal
Experimental brain research
Abbr.
Exp Brain Res
ISSN
0014-4819
DOI
10.1007/BF00247950
Published
1989-00-00
Pages
441-5
Language
English
Region
Germany
NLM ID
0043312
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00247950 View journal details
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