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PMID: 21917550 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Retracted Publication

The Xanthomonas type III effector XopD targets the Arabidopsis transcription factor MYB30 to suppress plant defense.

The Plant cell ·Vol. 23 ·No. 9 ·2011-00-00 ·Pages 3498-511

Canonne J, Marino D, Jauneau A, Pouzet C, Brière C, Roby D, Rivas S

Abstract

Plant and animal pathogens inject type III effectors (T3Es) into host cells to suppress host immunity and promote successful infection. XopD, a T3E from Xanthomonas campestris pv vesicatoria, has been proposed to promote bacterial growth by targeting plant transcription factors and/or regulators. Here, we show that XopD from the B100 strain of X. campestris pv campestris is able to target MYB30, a transcription factor that positively regulates Arabidopsis thaliana defense and associated cell death responses to bacteria through transcriptional activation of genes related to very-long-chain fatty acid (VLCFA) metabolism. XopD specifically interacts with MYB30, resulting in inhibition of the transcriptional activation of MYB30 VLCFA-related target genes and suppression of Arabidopsis defense. The helix-loop-helix domain of XopD is necessary and sufficient to mediate these effects. These results illustrate an original strategy developed by Xanthomonas to subvert plant defense and promote development of disease.

MeSH Terms
Arabidopsis/immunology,microbiology Arabidopsis Proteins/metabolism Bacterial Proteins/metabolism Gene Expression Regulation, Plant Helix-Loop-Helix Motifs Host-Pathogen Interactions Molecular Sequence Data Plant Diseases/microbiology Plant Immunity Structure-Activity Relationship Transcription Factors/metabolism Virulence Xanthomonas campestris/metabolism,pathogenicity
Chemicals
Arabidopsis Proteins Bacterial Proteins MYB30 protein, Arabidopsis Transcription Factors
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Canonne Joanne
Institut National de la Recherche Agronomique, Laboratoire des Interactions Plantes-Microorganismes, Unité Mixte de Recherche 441, Castanet-Tolosan, France.
Marino Daniel
Jauneau Alain
Pouzet Cécile
Brière Christian
Roby Dominique
Rivas Susana
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Article Info
Journal
The Plant cell
Abbr.
Plant Cell
ISSN
1532-298X
DOI
10.1105/tpc.111.088815
Published
2011-00-00
Epub
2011-00-13
Pages
3498-511
Language
English
Region
England
NLM ID
9208688
PMCID
PMC3203416
Subset
IM
Databases
GENBANK
BK007963
Corrections
ErratumIn
-
ErratumIn
PMID: 22086089
RetractionIn
PMID: 29255113
External Links
PubMed source DOI: 10.1105/tpc.111.088815 PMC Full Text View journal details
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