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PMID: 21808241 Published · epublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal.

Nature cell biology ·Vol. 13 ·No. 8 ·2011-08-01 ·Pages 877-83

Zhao B, Tumaneng K, Guan KL

Abstract

Precise control of organ size is crucial during animal development and regeneration. In Drosophila and mammals, studies over the past decade have uncovered a critical role for the Hippo tumour-suppressor pathway in the regulation of organ size. Dysregulation of this pathway leads to massive overgrowth of tissue. The Hippo signalling pathway is highly conserved and limits organ size by phosphorylating and inhibiting the transcription co-activators YAP and TAZ in mammals and Yki in Drosophila, key regulators of proliferation and apoptosis. The Hippo pathway also has a critical role in the self-renewal and expansion of stem cells and tissue-specific progenitor cells, and has important functions in tissue regeneration. Emerging evidence shows that the Hippo pathway is regulated by cell polarity, cell adhesion and cell junction proteins. In this review we summarize current understanding of the composition and regulation of the Hippo pathway, and discuss how cell polarity and cell adhesion proteins inform the role of this pathway in organ size control and regeneration.

MeSH Terms
Animals Cell Adhesion/physiology Cell Polarity/physiology Drosophila/cytology,physiology Drosophila Proteins/physiology Humans Intercellular Junctions/physiology Intracellular Signaling Peptides and Proteins/physiology Mice Models, Biological Organ Size/physiology Protein Serine-Threonine Kinases/physiology Regeneration/physiology Signal Transduction Stem Cells/cytology,physiology
Chemicals
Drosophila Proteins Intracellular Signaling Peptides and Proteins Protein Serine-Threonine Kinases hpo protein, Drosophila
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Zhao Bin
Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang 310058, China.
Tumaneng Karen
Guan Kun-Liang
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Article Info
Journal
Nature cell biology
Abbr.
Nat Cell Biol
ISSN
1476-4679
DOI
10.1038/ncb2303
Published
2011-08-01
Epub
2011-00-01
Pages
877-83
Language
English
Region
England
NLM ID
100890575
PMCID
PMC3987945
Subset
IM
Grants
NCI NIH HHS · R01 CA132809 · United States
NIGMS NIH HHS · R01 GM051586 · United States
NIGMS NIH HHS · T32 GM007752 · United States
External Links
PubMed source DOI: 10.1038/ncb2303 PMC Full Text View journal details
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