The role of phosphoenolpyruvate carboxykinase in amino acid metabolism in muscle.

The Biochemical journal ·Vol. 176 ·No. 2 ·1978-11-15 ·Pages 623-6

Newsholme EA, Williams T

Abstract

Starvation or feeding rats on a high-protein diet, valine or isoleucine, but not leucine, increases the activity of muscle phosphoenolpyruvate carboxykinase, but has no effect on NADP+-linked malate dehydrogenase. This suggests that muscle phosphoenolpyruvate carboxykinase is involved in oxidation or conversion of some amino acids to alanine.

MeSH Terms

Amino Acids/metabolism Animals Fructose-Bisphosphatase/metabolism Humans Malate Dehydrogenase/metabolism Muscles/enzymology Phosphoenolpyruvate Carboxykinase (GTP)/metabolism

Chemicals

Amino Acids Malate Dehydrogenase Fructose-Bisphosphatase Phosphoenolpyruvate Carboxykinase (GTP)

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Newsholme E A

Williams T

References (17)

17 references, click to expand

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Article Info

Journal

The Biochemical journal

Abbr.

Biochem J

ISSN

0264-6021

DOI

10.1042/bj1760623

Published

1978-11-15

Pages

623-6

Language

English

Region

England

NLM ID

2984726R

PMCID

PMC1186277

Subset

External Links

PubMed source DOI: 10.1042/bj1760623 PMC Full Text View journal details

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The role of phosphoenolpyruvate carboxykinase in amino acid metabolism in muscle.

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