Proportion of DNA gyrase mutants among quinolone-resistant strains of Pseudomonas aeruginosa.

Antimicrobial agents and chemotherapy ·Vol. 34 ·No. 6 ·1990-06-00 ·Pages 1273-5

Yoshida H, Nakamura M, Bogaki M, Nakamura S

Abstract

The proportion of DNA gyrase mutants among quinolone-resistant strains of Pseudomonas aeruginosa was examined by introducing the cloned wild-type Escherichia coli gyrA and gyrB genes. Of 101 spontaneous mutants of P. aeruginosa PAO505, 33 (33%) were found to have gyrA mutations. Among 17 clinical isolates, 12 (71%) had gyrA mutations and 1 (6%) had a gyrB mutation.

MeSH Terms

4-Quinolones Anti-Infective Agents/pharmacology DNA Topoisomerases, Type II/genetics Drug Resistance, Microbial/genetics Mutation Pseudomonas aeruginosa/drug effects,genetics Transformation, Genetic/physiology

Chemicals

4-Quinolones Anti-Infective Agents DNA Topoisomerases, Type II

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Yoshida H

Research Laboratories, Dainippon Pharmaceutical Co., Ltd., Osaka, Japan.

Nakamura M

Bogaki M

Nakamura S

References (17)

17 references, click to expand

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Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.34.6.1273

Published

1990-06-00

Pages

1273-5

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC171800

Subset

External Links

PubMed source DOI: 10.1128/AAC.34.6.1273 PMC Full Text View journal details

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Proportion of DNA gyrase mutants among quinolone-resistant strains of Pseudomonas aeruginosa.

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