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PMID: 21670596 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

mTOR complex 2 signaling and functions.

Cell cycle (Georgetown, Tex.) ·Vol. 10 ·No. 14 ·2011-07-15 ·Pages 2305-16

Oh WJ, Jacinto E

Abstract

The mechanistic target of rapamycin (mTOR) plays a central role in cellular growth and metabolism. mTOR forms two distinct protein complexes, mTORC1 and mTORC2. Much is known about the regulation and functions of mTORC1 due to availability of a natural compound, rapamycin, that inhibits this complex. Studies that define mTORC2 cellular functions and signaling have lagged behind. The development of pharmacological inhibitors that block mTOR kinase activity, and thereby inhibit both mTOR complexes, along with availability of mice with genetic knockouts in mTOR complex components have now provided new insights on mTORC2 function and regulation. Since prolonged effects of rapamycin can also disrupt mTORC2, it is worth re-evaluating the contribution of this less-studied mTOR complex in cancer, metabolic disorders and aging. In this review, we focus on recent developments on mammalian mTORC2 signaling mechanisms and its cellular and tissue-specific functions.

MeSH Terms
Actin Cytoskeleton Animals Carrier Proteins/metabolism Cell Movement Mice Mice, Knockout Protein Biosynthesis Rapamycin-Insensitive Companion of mTOR Protein Signal Transduction Trans-Activators/antagonists & inhibitors,metabolism,physiology Transcription Factors
Chemicals
Carrier Proteins Crtc2 protein, mouse Rapamycin-Insensitive Companion of mTOR Protein Trans-Activators Transcription Factors rictor protein, mouse stress-activated protein kinase-interacting protein, mouse
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Oh Won Jun
Department of Physiology and Biophysics, UMDNJ-Robert Wood Johnson Medical School, Piscataway, NJ, USA.
Jacinto Estela
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Article Info
Journal
Cell cycle (Georgetown, Tex.)
Abbr.
Cell Cycle
ISSN
1551-4005
DOI
10.4161/cc.10.14.16586
Published
2011-07-15
Epub
2011-00-15
Pages
2305-16
Language
English
Region
United States
NLM ID
101137841
PMCID
PMC3322468
Subset
IM
Grants
NIGMS NIH HHS · R01 GM079176 · United States
NIGMS NIH HHS · R01 GM079176-04 · United States
NIGMS NIH HHS · GM079176 · United States
External Links
PubMed source DOI: 10.4161/cc.10.14.16586 PMC Full Text View journal details
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