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PMID: 21652651 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Evolutionary plasticity of segmentation clock networks.

Development (Cambridge, England) ·Vol. 138 ·No. 13 ·2011-07-00 ·Pages 2783-92

Krol AJ, Roellig D, Dequéant ML, Tassy O, Glynn E, Hattem G, Mushegian A, Oates AC, Pourquié O

Abstract

The vertebral column is a conserved anatomical structure that defines the vertebrate phylum. The periodic or segmental pattern of the vertebral column is established early in development when the vertebral precursors, the somites, are rhythmically produced from presomitic mesoderm (PSM). This rhythmic activity is controlled by a segmentation clock that is associated with the periodic transcription of cyclic genes in the PSM. Comparison of the mouse, chicken and zebrafish PSM oscillatory transcriptomes revealed networks of 40 to 100 cyclic genes mostly involved in Notch, Wnt and FGF signaling pathways. However, despite this conserved signaling oscillation, the identity of individual cyclic genes mostly differed between the three species, indicating a surprising evolutionary plasticity of the segmentation networks.

MeSH Terms
Animals Biological Clocks/genetics,physiology Chickens Evolution, Molecular Fibroblast Growth Factors/genetics,metabolism In Situ Hybridization Mice Oligonucleotide Array Sequence Analysis Polymerase Chain Reaction Receptors, Notch/genetics,metabolism Signal Transduction/genetics,physiology Wnt Proteins/genetics,metabolism Zebrafish
Chemicals
Receptors, Notch Wnt Proteins Fibroblast Growth Factors
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Krol Aurélie J
Stowers Institute for Medical Research, Kansas City, MO 64110, USA.
Roellig Daniela
Dequéant Mary-Lee
Tassy Olivier
Glynn Earl
Hattem Gaye
Mushegian Arcady
Oates Andrew C
Pourquié Olivier
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Article Info
Journal
Development (Cambridge, England)
Abbr.
Development
ISSN
1477-9129
DOI
10.1242/dev.063834
Published
2011-07-00
Pages
2783-92
Language
English
Region
England
NLM ID
8701744
PMCID
PMC3109603
Subset
IM
Grants
NICHD NIH HHS · R01 HD043158 · United States
Howard Hughes Medical Institute · United States
NICHD NIH HHS · R02 HD043158 · United States
External Links
PubMed source DOI: 10.1242/dev.063834 PMC Full Text View journal details
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