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PMID: 21622178 Published · epublish English Journal Article Research Support, N.I.H., Extramural Review

Modulation of neoplastic gene regulatory pathways by the RNA-binding factor AUF1.

Frontiers in bioscience (Landmark edition) ·Vol. 16 ·2011-06-01 ·Pages 2307-25

Zucconi BE, Wilson GM

Abstract

The mRNA-binding protein AUF1 regulates the expression of many key players in cancer including proto-oncogenes, regulators of apoptosis and the cell cycle, and pro-inflammatory cytokines, principally by directing the decay kinetics of their encoded mRNAs. Most studies support an mRNA-destabilizing role for AUF1, although other findings suggest additional functions for this factor. In this review, we explore how changes in AUF1 isoform distribution, subcellular localization, and post-translational protein modifications can influence the metabolism of targeted mRNAs. However, several lines of evidence also support a role for AUF1 in the initiation and/or development of cancer. Many AUF1-targeted transcripts encode products that control pro- and anti-oncogenic processes. Also, overexpression of AUF1 enhances tumorigenesis in murine models, and AUF1 levels are enhanced in some tumors. Finally, signaling cascades that modulate AUF1 function are deregulated in some cancerous tissues. Together, these features suggest that AUF1 may play a prominent role in regulating the expression of many genes that can contribute to tumorigenic phenotypes, and that this post-transcriptional regulatory control point may be subverted by diverse mechanisms in neoplasia.

MeSH Terms
Animals Apoptosis/genetics,physiology Biological Transport, Active Cell Cycle/genetics,physiology Gene Expression Regulation, Neoplastic Heterogeneous Nuclear Ribonucleoprotein D0 Heterogeneous-Nuclear Ribonucleoprotein D/chemistry,genetics,metabolism Humans Mice Neoplasms/etiology,genetics,metabolism,pathology Phosphorylation Protein Isoforms/chemistry,genetics,metabolism RNA Processing, Post-Transcriptional RNA, Messenger/genetics,metabolism RNA, Neoplasm/genetics,metabolism
Chemicals
HNRNPD protein, human Heterogeneous Nuclear Ribonucleoprotein D0 Heterogeneous-Nuclear Ribonucleoprotein D Hnrpd protein, mouse Protein Isoforms RNA, Messenger RNA, Neoplasm
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Zucconi Beth E
Department of Biochemistry and Molecular Biology and Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, 108 N. Greene St., Baltimore, MD 21201, USA.
Wilson Gerald M
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Article Info
Journal
Frontiers in bioscience (Landmark edition)
Abbr.
Front Biosci (Landmark Ed)
ISSN
2768-6698
DOI
10.2741/3855
Published
2011-06-01
Epub
2011-00-01
Pages
2307-25
Language
English
Region
Singapore
NLM ID
101612996
PMCID
PMC3589912
Subset
IM
Grants
NCI NIH HHS · R01 CA102428 · United States
NIGMS NIH HHS · T32 GM066706 · United States
External Links
PubMed source DOI: 10.2741/3855 PMC Full Text View journal details
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