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PMID: 20495997 Published · ppublish English Journal Article Review

Post-transcriptional control during chronic inflammation and cancer: a focus on AU-rich elements.

Cellular and molecular life sciences : CMLS ·Vol. 67 ·No. 17 ·2010-09-00 ·Pages 2937-55

Khabar KS

Abstract

A considerable number of genes that code for AU-rich mRNAs including cytokines, growth factors, transcriptional factors, and certain receptors are involved in both chronic inflammation and cancer. Overexpression of these genes is affected by aberrations or by prolonged activation of several signaling pathways. AU-rich elements (ARE) are important cis-acting short sequences in the 3'UTR that mediate recognition of an array of RNA-binding proteins and affect mRNA stability and translation. This review addresses the cellular and molecular mechanisms that are common between inflammation and cancer and that also govern ARE-mediated post-transcriptional control. The first part examines the role of the ARE-genes in inflammation and cancer and sequence characteristics of AU-rich elements. The second part addresses the common signaling pathways in inflammation and cancer that regulate the ARE-mediated pathways and how their deregulations affect ARE-gene regulation and disease outcome.

MeSH Terms
3' Untranslated Regions/genetics Alternative Splicing/genetics Base Composition Cyclooxygenase 2/metabolism Gene Expression Regulation/physiology Humans Inflammation/metabolism Mitogen-Activated Protein Kinases/metabolism Models, Biological Neoplasms/metabolism Phosphatidylinositol 3-Kinases/metabolism RNA, Messenger/genetics,metabolism Signal Transduction/genetics,physiology Tumor Necrosis Factor-alpha/metabolism Vascular Endothelial Growth Factor A/metabolism
Chemicals
3' Untranslated Regions RNA, Messenger Tumor Necrosis Factor-alpha Vascular Endothelial Growth Factor A Cyclooxygenase 2 PTGS2 protein, human Phosphatidylinositol 3-Kinases Mitogen-Activated Protein Kinases
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Khabar Khalid S A
Program in BioMolecular Research, King Faisal Specialist Hospital and Research Center, Riyadh, 11211, Saudi Arabia. khabar@kfshrc.edu.sa
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Article Info
Journal
Cellular and molecular life sciences : CMLS
Abbr.
Cell Mol Life Sci
ISSN
1420-9071
DOI
10.1007/s00018-010-0383-x
Email
khabar@kfshrc.edu.sa
Published
2010-09-00
Epub
2010-00-22
Pages
2937-55
Language
English
Region
Switzerland
NLM ID
9705402
PMCID
PMC2921490
Subset
IM
External Links
PubMed source DOI: 10.1007/s00018-010-0383-x PMC Full Text View journal details
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