Tristetraprolin binds to the 3'-untranslated region of cyclooxygenase-2 mRNA. A polyadenylation variant in a cancer cell line lacks the binding site.

3' Untranslated Regions Base Sequence Binding Sites Blotting, Northern Blotting, Western Catalysis Cells, Cultured Cross-Linking Reagents/pharmacology Cyclooxygenase 2 DNA, Complementary/metabolism DNA-Binding Proteins Dose-Response Relationship, Drug Down-Regulation Endothelium, Vascular/cytology Humans Immediate-Early Proteins/chemistry,metabolism Isoenzymes/chemistry,metabolism Lipopolysaccharides/pharmacology Membrane Proteins Molecular Sequence Data Polyadenylation Precipitin Tests Prostaglandin-Endoperoxide Synthases/chemistry,metabolism Protein Binding RNA/metabolism RNA, Messenger/metabolism Ribonucleases/metabolism Time Factors Transcription, Genetic Transfection Tristetraprolin Tumor Cells, Cultured Umbilical Veins/cytology Up-Regulation

3' Untranslated Regions Cross-Linking Reagents DNA, Complementary DNA-Binding Proteins Immediate-Early Proteins Isoenzymes Lipopolysaccharides Membrane Proteins RNA, Messenger Tristetraprolin ZFP36 protein, human RNA Cyclooxygenase 2 PTGS2 protein, human Prostaglandin-Endoperoxide Synthases Ribonucleases