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PMID: 21547954 Published · ppublish English Journal Article Review

Cancer stem cells in gliomas: identifying and understanding the apex cell in cancer's hierarchy.

Glia ·Vol. 59 ·No. 8 ·2011-08-00 ·Pages 1148-54

Venere M, Fine HA, Dirks PB, Rich JN

Abstract

Neuro-oncology research has rediscovered a complexity of nervous system cancers through the incorporation of cellular heterogeneity into tumor models with cellular subsets displaying stem-cell characteristics. Self-renewing cancer stem cells (CSCs) can propagate tumors and yield nontumorigenic tumor bulk cells that display a more differentiated phenotype. The ability to prospectively isolate and interrogate CSCs is defining molecular mechanisms responsible for the tumor maintenance and growth. The clinical relevance of CSCs has been supported by their resistance to cytotoxic therapies and their promotion of tumor angiogenesis. Although the field of CSC biology is relatively young, continued elucidation of the features of these cells holds promise for the development of novel patient therapies. © 2011 Wiley-Liss, Inc.

MeSH Terms
Animals Disease Models, Animal Glioma/etiology,pathology Humans Mice Models, Biological Neoplastic Stem Cells/pathology,physiology Stem Cell Niche/pathology,physiopathology
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Venere Monica
Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Ohio, USA. venerem@ccf.org
Fine Howard A
Dirks Peter B
Rich Jeremy N
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Article Info
Journal
Glia
Abbr.
Glia
ISSN
1098-1136
DOI
10.1002/glia.21185
Email
venerem@ccf.org
Published
2011-08-00
Epub
2011-00-05
Pages
1148-54
Language
English
Region
United States
NLM ID
8806785
PMCID
PMC3107874
Subset
IM
Grants
NCI NIH HHS · R01 CA116659 · United States
NINDS NIH HHS · F32 NS058042 · United States
NCI NIH HHS · R01 CA129958 · United States
NINDS NIH HHS · F32 NS058042-04 · United States
NINDS NIH HHS · R01 NS054276 · United States
NCI NIH HHS · R01 CA154130 · United States
External Links
PubMed source DOI: 10.1002/glia.21185 PMC Full Text View journal details
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