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PMID: 21502992 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22.

Nature immunology ·Vol. 12 ·No. 5 ·2011-05-00 ·Pages 383-90

Sonnenberg GF, Fouser LA, Artis D

Abstract

The maintenance of barrier function at exposed surfaces of the mammalian body is essential for limiting exposure to environmental stimuli, preventing systemic dissemination of commensal and pathogenic microbes and retaining normal homeostasis of the entire body. Indeed, dysregulated barrier function is associated with many infectious and inflammatory diseases, including psoriasis, influenza, inflammatory bowel disease and human immunodeficiency virus, which collectively afflict millions of people worldwide. Studies have shown that interleukin 22 (IL-22) is expressed at barrier surfaces and that its expression is dysregulated in certain human diseases, which suggests a critical role in the maintenance of normal barrier homeostasis. Consistent with that, studies of mouse model systems have identified a critical role for signaling by IL-22 through its receptor (IL-22R) in the promotion of antimicrobial immunity, inflammation and tissue repair at barrier surfaces. In this review we will discuss how the expression of IL-22 and IL-22R is regulated, the functions of the IL-22-IL-22R pathway in regulating immunity, inflammation and tissue homeostasis, and the therapeutic potential of targeting this pathway in human disease.

MeSH Terms
Adaptive Immunity/immunology Animals Humans Immunity, Innate/immunology Inflammation/immunology Interleukins/immunology Intestines/immunology Mice Models, Animal Receptors, Interleukin/immunology Respiratory System/immunology Signal Transduction/immunology Skin/immunology
Chemicals
Interleukins Receptors, Interleukin interleukin-22 receptor interleukin-22
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Sonnenberg Gregory F
Department of Microbiology and Institute for Immunology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Fouser Lynette A
Artis David
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Article Info
Journal
Nature immunology
Abbr.
Nat Immunol
ISSN
1529-2916
DOI
10.1038/ni.2025
Published
2011-05-00
Pages
383-90
Language
English
Region
United States
NLM ID
100941354
Subset
IM
Grants
NIAID NIH HHS · T32AI007532-08 · United States
NIAID NIH HHS · AI087990 · United States
NIAID NIH HHS · AI083480 · United States
NIAID NIH HHS · AI74878 · United States
NIAID NIH HHS · AI61570 · United States
External Links
PubMed source DOI: 10.1038/ni.2025 View journal details
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