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PMID: 21472002 Published · ppublish English Journal Article Research Support, N.I.H., Intramural Research Support, U.S. Gov't, Non-P.H.S. Review

Brain metastases as preventive and therapeutic targets.

Nature reviews. Cancer ·Vol. 11 ·No. 5 ·2011-05-00 ·Pages 352-63

Steeg PS, Camphausen KA, Smith QR

Abstract

The incidence of metastasis to the brain is apparently rising in cancer patients and threatens to limit the gains that have been made by new systemic treatments. The brain is considered a 'sanctuary site' as the blood-tumour barrier limits the ability of drugs to enter and kill tumour cells. Translational research examining metastasis to the brain needs to be multi-disciplinary, marrying advanced chemistry, blood-brain barrier pharmacokinetics, neurocognitive testing and radiation biology with metastasis biology, to develop and implement new clinical trial designs. Advances in the chemoprevention of brain metastases, the validation of tumour radiation sensitizers and the amelioration of cognitive deficits caused by whole-brain radiation therapy are discussed.

MeSH Terms
Antineoplastic Agents/pharmacokinetics,therapeutic use Blood-Brain Barrier/metabolism Brain Neoplasms/pathology,secondary,therapy Humans
Chemicals
Antineoplastic Agents
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Steeg Patricia S
National Cancer Institute, Bethesda, MD 20892, USA. steegp@mail.nih.gov
Camphausen Kevin A
Smith Quentin R
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Article Info
Journal
Nature reviews. Cancer
Abbr.
Nat Rev Cancer
ISSN
1474-1768
DOI
10.1038/nrc3053
Email
steegp@mail.nih.gov
Published
2011-05-00
Epub
2011-00-07
Pages
352-63
Language
English
Region
England
NLM ID
101124168
PMCID
PMC7351203
Subset
IM
Grants
Intramural NIH HHS · Z01 BC010538 · United States
Intramural NIH HHS · Z01 BC010538-05 · United States
External Links
PubMed source DOI: 10.1038/nrc3053 PMC Full Text View journal details
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