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PMID: 21442426 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

Transcriptional regulation by STAT6.

Immunologic research ·Vol. 50 ·No. 1 ·2011-05-00 ·Pages 87-96

Goenka S, Kaplan MH

Abstract

Signal transducer and activator of transcription (STAT) proteins are critical mediators of cytokine signaling. Among the seven STAT proteins, STAT6 is activated by IL-4 and IL-13 and plays a predominant role in the immune system. However, there is increasing evidence that STAT6 may function in other tissues and organ systems. IL-4, IL-13, and STAT6 promote humoral immunity, clearance of helminthic parasites as well as the pathogenesis of allergic disorders like asthma, food allergies, and atopic dermatitis. In this review, we will describe our current understanding of the biological functions of STAT6 and summarize recent advances in understanding the molecular mechanisms by which STAT6 regulates transcription.

MeSH Terms
Animals Consensus Sequence/genetics DNA/genetics,metabolism DNA-Binding Proteins/metabolism Enhancer Elements, Genetic/genetics Gene Expression Regulation Humans Lymphocytes/metabolism STAT6 Transcription Factor/immunology,metabolism
Chemicals
DNA-Binding Proteins STAT6 Transcription Factor DNA
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Goenka Shreevrat
HB Wells Center of Pediatric Research, Department of Pediatrics, Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, 46202, USA. goenkas@iupui.edu
Kaplan Mark H
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Article Info
Journal
Immunologic research
Abbr.
Immunol Res
ISSN
1559-0755
DOI
10.1007/s12026-011-8205-2
Email
goenkas@iupui.edu
Published
2011-05-00
Pages
87-96
Language
English
Region
United States
NLM ID
8611087
PMCID
PMC3107597
Subset
IM
Grants
NIAID NIH HHS · U19 AI070448 · United States
NHLBI NIH HHS · R01 HL093105 · United States
NIAID NIH HHS · R01 AI057459-06 · United States
NIAID NIH HHS · R01 AI057459 · United States
NHLBI NIH HHS · HL093105 · United States
NIAID NIH HHS · AI070448 · United States
NIAID NIH HHS · U19 AI070448-05 · United States
NIAID NIH HHS · AI057459 · United States
NHLBI NIH HHS · R01 HL093105-02 · United States
External Links
PubMed source DOI: 10.1007/s12026-011-8205-2 PMC Full Text View journal details
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