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PMID: 21434937 Published · ppublish English Evaluation Study Journal Article Review

Advances in the diagnosis of respiratory tract infections: role of the Luminex xTAG respiratory viral panel.

Annals of the New York Academy of Sciences ·Vol. 1222 ·2011-03-00 ·Pages 6-13

Krunic N, Merante F, Yaghoubian S, Himsworth D, Janeczko R

Abstract

Clinical laboratories providing an etiological diagnosis of respiratory tract infections (RTI) have increasingly relied on nucleic acid amplification tests. Polymerase chain reaction-based methods are becoming more standardized, and several have undergone the scrutiny of regulatory agencies mandated to assess the risks and benefits of implementing pathogen-detection assays into diagnostic algorithms. Respiratory viruses lead to both upper and lower RTI and are implicated in exacerbations of chronic pulmonary conditions. Viruses from different taxonomic families present with overlapping clinical signs and symptoms, necessitating an accurate laboratory diagnosis. The clinical utility of diagnostic algorithms incorporating tests for respiratory viruses will depend on the breadth of pathogen coverage and the time to reliable and actionable results. This review covers strategies for detecting a panel of respiratory viruses employed over the last decade that have enabled an etiological diagnosis of RTI in a cost-effective manner.

MeSH Terms
Clinical Laboratory Techniques/trends DNA, Viral/analysis Humans Influenza A Virus, H1N1 Subtype/genetics,isolation & purification Influenza, Human/diagnosis,epidemiology Nucleic Acid Amplification Techniques/economics,instrumentation,methods,trends Respiratory System/virology Respiratory Tract Infections/diagnosis,virology Virology/economics,methods,trends
Chemicals
DNA, Viral
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Krunic Nancy
Luminex Molecular Diagnostics, Toronto, Ontario, Canada. nkrunic@luminexcorp.com
Merante Frank
Yaghoubian Sevana
Himsworth David
Janeczko Richard
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Article Info
Journal
Annals of the New York Academy of Sciences
Abbr.
Ann N Y Acad Sci
ISSN
1749-6632
DOI
10.1111/j.1749-6632.2011.05964.x
Email
nkrunic@luminexcorp.com
Published
2011-03-00
Pages
6-13
Language
English
Region
United States
NLM ID
7506858
PMCID
PMC7168110
Subset
IM
External Links
PubMed source DOI: 10.1111/j.1749-6632.2011.05964.x PMC Full Text View journal details
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