The effect of cGMP in rabbit auricle as studied by a cut-end method.

Naunyn-Schmiedeberg's archives of pharmacology ·Vol. 304 ·No. 3 ·1978-10-00 ·Pages 211-3

Tuganowski W, Kopeć P

Abstract

Cyclic GMP was applied to the rabbit right auricle by a cut-end method. The nucleotide decreased the spontaneous rate, hyperpolarized the cell membrane and reduced the amplitude and the slow component of the action potential. It also decreased the force of contraction. These results suggest that cGMP may be the mediator of the action of acetylcholine in the rabbit auricle.

MeSH Terms

Action Potentials/drug effects Animals Cyclic GMP/pharmacology Heart/drug effects In Vitro Techniques Myocardial Contraction/drug effects Potassium Chloride/pharmacology Rabbits Theophylline/pharmacology

Chemicals

Potassium Chloride Theophylline Cyclic GMP

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Tuganowski W

Kopeć P

References (16)

16 references, click to expand

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Article Info

Journal

Naunyn-Schmiedeberg's archives of pharmacology

Abbr.

Naunyn Schmiedebergs Arch Pharmacol

ISSN

0028-1298

DOI

10.1007/BF00507960

Published

1978-10-00

Pages

211-3

Language

English

Region

Germany

NLM ID

0326264

Subset

External Links

PubMed source DOI: 10.1007/BF00507960 View journal details

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The effect of cGMP in rabbit auricle as studied by a cut-end method.

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