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PMID: 21135249 Published · ppublish English Comment Journal Article

And four equals one: presenilin takes the gamma-secretase role by itself.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 107 ·No. 50 ·2010-12-14 ·Pages 21236-7

Lessard CB, Wagner SL, Koo EH

Abstract

暂无摘要

MeSH Terms
Alzheimer Disease Amyloid Precursor Protein Secretases/metabolism Amyloid beta-Protein Precursor/metabolism Enzyme Activation Humans Mutation Presenilin-1/chemistry,genetics,metabolism
Chemicals
Amyloid beta-Protein Precursor Presenilin-1 Amyloid Precursor Protein Secretases
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Lessard Christian B
Department of Neurosciences, University of California at San Diego, La Jolla, CA 92093, USA.
Wagner Steven L
Koo Edward H
References (14)
14 references, click to expand
  1. Presenilins: members of the gamma-secretase quartets, but part-time soloists too.
    Physiology (Bethesda). 2008 Aug;23:194-204 PMID: 18697993
  2. Reconstitution of gamma-secretase activity.
    Nat Cell Biol. 2003 May;5(5):486-8 PMID: 12679784
  3. gamma-Secretase: successive tripeptide and tetrapeptide release from the transmembrane domain of beta-carboxyl terminal fragment.
    J Neurosci. 2009 Oct 14;29(41):13042-52 PMID: 19828817
  4. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor.
    Nature. 1987 Feb 19-25;325(6106):733-6 PMID: 2881207
  5. Active gamma-secretase complexes contain only one of each component.
    J Biol Chem. 2007 Nov 23;282(47):33985-93 PMID: 17911105
  6. Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein.
    Nature. 1998 Jan 22;391(6665):387-90 PMID: 9450754
  7. Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1.
    Nature. 2000 Jun 8;405(6787):689-94 PMID: 10864326
  8. Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process.
    Physiol Rev. 2010 Apr;90(2):465-94 PMID: 20393191
  9. PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.
    J Biol Chem. 2003 Mar 7;278(10):7850-4 PMID: 12522139
  10. Activation and intrinsic gamma-secretase activity of presenilin 1.
    Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21435-40 PMID: 21115843
  11. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity.
    Nature. 1999 Apr 8;398(6727):513-7 PMID: 10206644
  12. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease.
    Nature. 1995 Jun 29;375(6534):754-60 PMID: 7596406
  13. Gamma-secretase: proteasome of the membrane?
    Nat Rev Mol Cell Biol. 2004 Jun;5(6):499-504 PMID: 15173829
  14. Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo.
    Neuron. 1996 Jul;17(1):181-90 PMID: 8755489
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
1091-6490
DOI
10.1073/pnas.1016284108
Published
2010-12-14
Epub
2010-00-06
Pages
21236-7
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC3003118
Subset
IM
Corrections
CommentOn
PMID: 21115843
External Links
PubMed source DOI: 10.1073/pnas.1016284108 PMC Full Text View journal details
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