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PMID: 18697993 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Presenilins: members of the gamma-secretase quartets, but part-time soloists too.

Physiology (Bethesda, Md.) ·Vol. 23 ·2008-08-00 ·Pages 194-204

Wakabayashi T, De Strooper B

Abstract

The presenilins in combination with other proteins generate different gamma-secretases, which are involved in the regulated intramembrane proteolysis of a variety of proteins. Understanding the specificity and regulation of these proteases will potentially lead to novel therapeutics for Alzheimer's disease and cancer. Presenilins appear also to exert additional functions outside of the gamma-secretase quartets, which needs further investigation.

MeSH Terms

Alzheimer Disease/genetics,metabolism Amino Acid Sequence Amyloid Precursor Protein Secretases/metabolism Animals Humans Molecular Sequence Data Multigene Family/physiology Presenilins/genetics,metabolism Signal Transduction/physiology Substrate Specificity

Chemicals

Presenilins Amyloid Precursor Protein Secretases

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Wakabayashi Tomoko

Department for Developmental and Molecular Genetics, VIB, Leuven.

De Strooper Bart

Article Info

Journal

Physiology (Bethesda, Md.)

Abbr.

Physiology (Bethesda)

ISSN

1548-9213

DOI

10.1152/physiol.00009.2008

Published

2008-08-00

Pages

194-204

Language

English

Region

United States

NLM ID

101208185

Subset

External Links

PubMed source DOI: 10.1152/physiol.00009.2008 View journal details

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Presenilins: members of the gamma-secretase quartets, but part-time soloists too.

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