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PMID: 211270 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Proteolysis of noncapsid protein 2 of type 3 poliovirus at the restrictive temperature: breakdown of noncapsid protein 2 correlates with loss of RNA synthesis.

Journal of virology ·Vol. 27 ·No. 2 ·1978-08-00 ·Pages 443-8

Bowles SA, Tershak DR

Abstract

Inhibition of RNA synthesis of the LH strain of type 3 poliovirus at the restrictive temperature occurs concurrently with the breakdown of noncapsid virus-specific peptide 2. This finding, along with other reported data (B.D. Korant, In Proteases and Biological Control, p. 621-644, 1975), suggests that noncapsid virus-specific peptide 2 is a component of the viral replicase.

MeSH Terms
Peptide Biosynthesis Poliovirus/metabolism Protein Conformation Protein Precursors/metabolism RNA, Viral/biosynthesis Temperature Viral Proteins/biosynthesis,metabolism
Chemicals
Protein Precursors RNA, Viral Viral Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Bowles S A
Tershak D R
References (11)
11 references, click to expand
  1. Effect of hypertonic medium on protein synthesis of Mahoney and LSc poliovirus.
    J Virol. 1976 Dec;20(3):597-603 PMID: 186637
  2. Isolation of a viral polypeptide associated with poliovirus RNA polymerase.
    Proc Natl Acad Sci U S A. 1974 Dec;71(12):4773-7 PMID: 4373729
  3. Association of the polioviral RNA polymerase complex with phospholipid membranes.
    J Virol. 1976 Aug;19(2):457-66 PMID: 183011
  4. Selective and reversible inhibition of initiation of protein synthesis in mammalian cells.
    J Mol Biol. 1974 May 15;85(2):195-211 PMID: 4365420
  5. Temperature-sensitive defect of type 2 poliovirus.
    Virology. 1974 Mar;58(1):209-18 PMID: 4362546
  6. Further characterization of the genetic map of poliovirus temperature-sensitive mutants. In: strategy of the viral genome.
    Ciba Found Symp. 1971;:75-100 PMID: 4337209
  7. Proteins associated with the poliovirus RNA replication complex.
    Virology. 1971 Nov;46(2):375-86 PMID: 4331730
  8. Determination of the gene sequence of poliovirus with pactamycin.
    Proc Natl Acad Sci U S A. 1971 Nov;68(11):2852-6 PMID: 4330946
  9. Effect of pactamycin on synthesis of poliovirus proteins: a method for genetic mapping.
    J Virol. 1971 Oct;8(4):395-401 PMID: 4331648
  10. Virus-specific proteins associated with the replication complex of poliovirus RNA.
    J Gen Virol. 1975 Jul;28(1):85-98 PMID: 169319
  11. Poliovirus proteins associated with the replication complex in infected cells.
    J Gen Virol. 1976 Jan;30(1):63-71 PMID: 173800
Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.27.2.443-448.1978
Published
1978-08-00
Pages
443-8
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC354183
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.27.2.443-448.1978 PMC Full Text View journal details
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