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PMID: 21102610 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Asymmetric cell division: recent developments and their implications for tumour biology.

Nature reviews. Molecular cell biology ·Vol. 11 ·No. 12 ·2010-12-00 ·Pages 849-60

Knoblich JA

Abstract

The ability of cells to divide asymmetrically is essential for generating diverse cell types during development. The past 10 years have seen tremendous progress in our understanding of this important biological process. We have learned that localized phosphorylation events are responsible for the asymmetric segregation of cell fate determinants in mitosis and that centrosomes and microtubules play important parts in this process. The relevance of asymmetric cell division for stem cell biology has added a new dimension to the field, and exciting connections between asymmetric cell division and tumorigenesis have begun to emerge.

MeSH Terms
Animals Cell Biology/trends Cell Division/physiology Cell Polarity/physiology Cell Size Centrosome/physiology Humans Models, Biological Neoplasms/etiology,pathology Vertebrates/physiology
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Knoblich Juergen A
Institute of Molecular Biotechnology of Austrian Academy of Science, Doktor Bohr-Gasse 3, 1030 Vienna, Austria. juergen.knoblich@imba.oeaw.ac.at
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Article Info
Journal
Nature reviews. Molecular cell biology
Abbr.
Nat Rev Mol Cell Biol
ISSN
1471-0080
DOI
10.1038/nrm3010
Email
juergen.knoblich@imba.oeaw.ac.at
Published
2010-12-00
Pages
849-60
Language
English
Region
England
NLM ID
100962782
PMCID
PMC3941022
Subset
IM
Grants
European Research Council · 250342 · International
External Links
PubMed source DOI: 10.1038/nrm3010 PMC Full Text View journal details
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