Abstract
A prime goal in systems biology is the comprehensive use of existing high-throughput genomic datasets to gain a better understanding of chromatin organization and genome function. In this report, we use chromatin immunoprecipitation (ChIP) data that map protein-binding sites on the genome, and Hi-C data that map interactions between DNA fragments in the genome in an integrative approach. We first reanalyzed the contact map of the human genome as determined with Hi-C and found that long-range interactions are highly nonrandom; the same DNA fragments are often found interacting together. We then show using ChIP data that these interactions can be explained by the action of the CCCTC-binding factor (CTCF). These CTCF-mediated interactions are found both within chromosomes and in between different chromosomes. This makes CTCF a major organizer of both the structure of the chromosomal fiber within each individual chromosome and of the chromosome territories within the cell nucleus.
MeSH Terms
Binding Sites
CCCTC-Binding Factor
Cell Line
Cell Nucleus/genetics,metabolism
Chromatin/chemistry
Chromatin Immunoprecipitation
Chromosomes, Human/chemistry,genetics,metabolism
DNA/chemistry,metabolism
Gene Regulatory Networks
Genome, Human
Genome-Wide Association Study
Humans
Protein Binding
Repressor Proteins/chemistry,genetics,metabolism
Systems Biology/methods
Chemicals
CCCTC-Binding Factor
CTCF protein, human
Chromatin
Repressor Proteins
DNA
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Botta Marco
Computer Laboratory, Cambridge University, Cambridge, UK.
Haider Syed
Leung Ian X Y
Lio Pietro
Mozziconacci Julien
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