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PMID: 21029957 Published · ppublish English Journal Article Review

From vaccines to memory and back.

Immunity ·Vol. 33 ·No. 4 ·2010-10-29 ·Pages 451-63

Sallusto F, Lanzavecchia A, Araki K, Ahmed R

Abstract

Vaccines work by eliciting an immune response and consequent immunological memory that mediates protection from infection or disease. Recently, new methods have been developed to dissect the immune response in experimental animals and humans, which have led to increased understanding of the molecular mechanisms that control differentiation and maintenance of memory T and B cells. In this review we will provide an overview of the cellular organization of immune memory and underline some of the outstanding questions on immunological memory and how they pertain to vaccination strategies. Finally we will discuss how we can learn about antigen design from the interrogation of our memory T and B cells-a journey from vaccines to memory and back.

MeSH Terms
Antibodies, Monoclonal/isolation & purification B-Lymphocytes/immunology Cell Differentiation Drug Design Humans Immunity Immunologic Memory T-Lymphocytes/immunology Vaccination Vaccines/immunology
Chemicals
Antibodies, Monoclonal Vaccines
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Sallusto Federica
Institute for Research in Biomedicine, CH-6500 Bellinzona, Switzerland. federica.sallusto@irb.unisi.ch
Lanzavecchia Antonio
Araki Koichi
Ahmed Rafi
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Article Info
Journal
Immunity
Abbr.
Immunity
ISSN
1097-4180
DOI
10.1016/j.immuni.2010.10.008
Email
federica.sallusto@irb.unisi.ch
Published
2010-10-29
Pages
451-63
Language
English
Region
United States
NLM ID
9432918
PMCID
PMC3760154
Subset
IM
Grants
NIAID NIH HHS · R01 AI030048 · United States
NIAID NIH HHS · R01 AI030048-20 · United States
External Links
PubMed source DOI: 10.1016/j.immuni.2010.10.008 PMC Full Text View journal details
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