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PMID: 20980922 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Role of microRNAs in cardiac preconditioning.

Journal of cardiovascular pharmacology ·Vol. 56 ·No. 6 ·2010-12-00 ·Pages 581-8

Salloum FN, Yin C, Kukreja RC

Abstract

Preconditioning (PC) of the heart by sublethal ischemia, mild heat shock, or hypoxia has evolved as a powerful experimental tool to discover novel signaling mechanisms in cardioprotection. The ultimate goal is to determine novel therapeutic targets for potential application in humans to protect the heart against ischemia-related injuries. In recent years, there has been a tremendous interest in understanding the role of small noncoding RNAs, microRNAs (miRs), in cardiovascular diseases. miRs have been recognized as regulators of gene expression by destabilization and translational inhibition of target messenger RNAs. Studies have shown that several miRs, including miR-1, miR-133, miR-21, miR-126, miR-320, miR-92a, and miR-199a, are regulated after preconditioning and play an active role in protecting the heart against ischemia/reperfusion injury. These miRs also drive the synthesis of important cardioprotective proteins including heat shock protein (HSP)-70, endothelial nitric oxide synthase, inducible nitric oxide synthase, HSP-20, Sirt1, and hypoxia-inducible factor 1a. We believe that identification and targeted delivery of miR(s) in the heart could have an immense therapeutic potential in reducing myocardial infarction in patients suffering from heart disease.

MeSH Terms
Animals Genetic Therapy/methods,trends Humans Ischemic Preconditioning, Myocardial/methods,trends MicroRNAs/physiology,therapeutic use Myocardial Reperfusion Injury/genetics,prevention & control Neovascularization, Pathologic/genetics,prevention & control
Chemicals
MicroRNAs
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Salloum Fadi N
Division of Cardiology, Pauley Heart Center, Department of Internal Medicine, Virginia Commonwealth University, 1101 East Marshall St, Richmond, VA 23298, USA.
Yin Chang
Kukreja Rakesh C
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Article Info
Journal
Journal of cardiovascular pharmacology
Abbr.
J Cardiovasc Pharmacol
ISSN
1533-4023
DOI
10.1097/FJC.0b013e3181f581ba
Published
2010-12-00
Pages
581-8
Language
English
Region
United States
NLM ID
7902492
PMCID
PMC4230440
Subset
IM
Grants
NHLBI NIH HHS · R37 HL051045 · United States
NHLBI NIH HHS · R01 HL093685 · United States
NHLBI NIH HHS · R01 HL079424 · United States
NHLBI NIH HHS · HL79424 · United States
NHLBI NIH HHS · R01 HL059469 · United States
NHLBI NIH HHS · HL51045 · United States
NHLBI NIH HHS · R01 HL051045 · United States
NHLBI NIH HHS · HL59469 · United States
External Links
PubMed source DOI: 10.1097/FJC.0b013e3181f581ba PMC Full Text View journal details
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