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PMID: 19325160 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

MicroRNA regulation of cardiovascular development.

Circulation research ·Vol. 104 ·No. 6 ·2009-03-27 ·Pages 724-32

Cordes KR, Srivastava D

Abstract

The transcriptional regulation of cardiovascular development requires precise spatiotemporal control of gene expression, and heterozygous mutations of transcription factors have frequently been implicated in human cardiovascular malformations. A novel mechanism involving posttranscriptional regulation by small, noncoding microRNAs (miRNAs) has emerged as a central regulator of many cardiogenic processes. We are beginning to understand the functions that miRNAs play during essential biological processes, such as cell proliferation, differentiation, apoptosis, stress response, and tumorigenesis. The identification of miRNAs expressed in specific cardiac and vascular cell types has led to the discovery of important regulatory roles for these small RNAs during cardiomyocyte differentiation, cell cycle, conduction, vessel formation, and during stages of cardiac hypertrophy in the adult. Here, we overview the recent findings on miRNA regulation in cardiovascular development and report the latest advances in understanding their function by unveiling their mRNA targets. Further analysis of miRNA function during cardiovascular development will allow us to determine the potential for novel miRNA-based therapeutic strategies.

MeSH Terms
Animals Apoptosis/physiology Cardiomegaly/genetics,metabolism Cell Differentiation/physiology Cell Proliferation Cell Transformation, Neoplastic/genetics,metabolism Gene Expression Regulation, Developmental/physiology Heart/embryology Humans MicroRNAs/biosynthesis,genetics Muscle Proteins/biosynthesis,genetics Neovascularization, Physiologic/physiology RNA, Messenger/biosynthesis,genetics
Chemicals
MicroRNAs Muscle Proteins RNA, Messenger
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Cordes Kimberly R
Gladstone Institute of Cardiovascular Disease, 1650 Owens St, San Francisco, CA 94158, USA.
Srivastava Deepak
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Article Info
Journal
Circulation research
Abbr.
Circ Res
ISSN
1524-4571
DOI
10.1161/CIRCRESAHA.108.192872
Published
2009-03-27
Pages
724-32
Language
English
Region
United States
NLM ID
0047103
PMCID
PMC2664538
Subset
IM
Grants
NHLBI NIH HHS · R01 HL057181-11 · United States
NHLBI NIH HHS · R01 HL057181-13 · United States
NHLBI NIH HHS · R01 HL080592-06 · United States
NHLBI NIH HHS · R01 HL062591-08 · United States
NHLBI NIH HHS · R01 HL057181 · United States
NHLBI NIH HHS · R01 HL080592 · United States
NHLBI NIH HHS · R01 HL057181-12 · United States
NHLBI NIH HHS · R01 HL062591 · United States
NHLBI NIH HHS · R01 HL080592-04 · United States
NHLBI NIH HHS · R01 HL080592-05 · United States
NHLBI NIH HHS · R01 HL062591-07 · United States
NHLBI NIH HHS · R01 HL062591-09 · United States
External Links
PubMed source DOI: 10.1161/CIRCRESAHA.108.192872 PMC Full Text View journal details
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