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PMID: 20838416 Published · ppublish English Journal Article Review

Renal fibrosis: novel insights into mechanisms and therapeutic targets.

Nature reviews. Nephrology ·Vol. 6 ·No. 11 ·2010-11-00 ·Pages 643-56

Boor P, Ostendorf T, Floege J

Abstract

Renal fibrosis is the common end point of virtually all progressive kidney diseases. Renal fibrosis should not be viewed as a simple and uniform 'scar', but rather as a dynamic system that involves extracellular matrix components and many, if not all, renal and infiltrating cell types. The involved cells exhibit enormous plasticity or phenotypic variability-a fact that we are only beginning to appreciate. Only a detailed understanding of the underlying mechanisms of renal fibrosis can facilitate the development of effective treatments. In this Review, we discuss the most recent advances in renal, or more specifically, tubulointerstitial fibrosis. Novel mechanisms as well as potential treatment targets based on different cell types are described. Problems that continue to plague the field are also discussed, including specific therapeutic targeting of the kidney, the development of improved diagnostic methods to assess renal fibrosis and the shortcomings of available animal models.

MeSH Terms
Fibrosis Humans Nephritis, Interstitial/pathology,therapy Renal Insufficiency, Chronic/pathology,therapy
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Boor Peter
Department of Nephrology, RWTH University of Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany.
Ostendorf Tammo
Floege Jürgen
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Article Info
Journal
Nature reviews. Nephrology
Abbr.
Nat Rev Nephrol
ISSN
1759-507X
DOI
10.1038/nrneph.2010.120
Published
2010-11-00
Epub
2010-00-14
Pages
643-56
Language
English
Region
England
NLM ID
101500081
Subset
IM
External Links
PubMed source DOI: 10.1038/nrneph.2010.120 View journal details
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