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PMID: 20032960 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

T cells and dendritic cells in glomerular disease: the new glomerulotubular feedback loop.

Kidney international ·Vol. 77 ·No. 5 ·2010-03-00 ·Pages 393-9

Sung SS, Bolton WK

Abstract

A newly described glomerulotubular feedback loop may explain the relationship between glomerular damage, epitope spreading, tubulointerstitial nephritis, proteinuria as a progression factor, and the importance of the local milieu in kidney damage. It also opens the horizons for exciting innovative approaches to therapy of both acute and chronic kidney diseases.

MeSH Terms
Animals Dendritic Cells/immunology Feedback, Physiological Humans Kidney Diseases/immunology,pathology Kidney Glomerulus/immunology,pathology Kidney Tubules/immunology,pathology Models, Immunological T-Lymphocytes/immunology
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Sung Sun-Sang
Division of Nephrology, University of Virginia, Charlottesville, Virginia 22908-0133, USA.
Bolton Warren K
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Article Info
Journal
Kidney international
Abbr.
Kidney Int
ISSN
1523-1755
DOI
10.1038/ki.2009.489
Published
2010-03-00
Epub
2009-00-23
Pages
393-9
Language
English
Region
United States
NLM ID
0323470
PMCID
PMC3039448
Subset
IM
Grants
NIAID NIH HHS · R21 AI079906-01 · United States
NIDDK NIH HHS · R01 DK055801-02 · United States
NIDDK NIH HHS · R01 DK055801-03 · United States
NIDDK NIH HHS · DK55801 · United States
NIAID NIH HHS · R21 AI079906 · United States
NIAID NIH HHS · AI079906 · United States
NIDDK NIH HHS · R01 DK055801-01 · United States
NIAID NIH HHS · R21 AI079906-02 · United States
NIAID NIH HHS · R21 AI079906-01S1 · United States
External Links
PubMed source DOI: 10.1038/ki.2009.489 PMC Full Text View journal details
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