Abstract
High-throughput technologies are widely used, for example to assay genetic variants, gene and protein expression, and epigenetic modifications. One often overlooked complication with such studies is batch effects, which occur because measurements are affected by laboratory conditions, reagent lots and personnel differences. This becomes a major problem when batch effects are correlated with an outcome of interest and lead to incorrect conclusions. Using both published studies and our own analyses, we argue that batch effects (as well as other technical and biological artefacts) are widespread and critical to address. We review experimental and computational approaches for doing so.
MeSH Terms
Biotechnology/methods,standards,statistics & numerical data
Computational Biology/methods
Genomics/methods,standards,statistics & numerical data
Oligonucleotide Array Sequence Analysis/methods,standards,statistics & numerical data
Periodicals as Topic/standards
Research Design/standards,statistics & numerical data
Sequence Analysis, DNA/methods,standards,statistics & numerical data
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Leek Jeffrey T
Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205-2179, USA.
Scharpf Robert B
Bravo Héctor Corrada
Simcha David
Langmead Benjamin
Johnson W Evan
Geman Donald
Baggerly Keith
Irizarry Rafael A
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