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PMID: 14685227 Published · ppublish English Journal Article Multicenter Study Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

The International HapMap Project.

Nature ·Vol. 426 ·No. 6968 ·2003-12-18 ·Pages 789-96

International HapMap Consortium

Abstract

The goal of the International HapMap Project is to determine the common patterns of DNA sequence variation in the human genome and to make this information freely available in the public domain. An international consortium is developing a map of these patterns across the genome by determining the genotypes of one million or more sequence variants, their frequencies and the degree of association between them, in DNA samples from populations with ancestry from parts of Africa, Asia and Europe. The HapMap will allow the discovery of sequence variants that affect common disease, will facilitate development of diagnostic tools, and will enhance our ability to choose targets for therapeutic intervention.

Keywords
Biomedical and Behavioral Research Empirical Approach Genetics and Reproduction
MeSH Terms
Base Sequence DNA/genetics Gene Frequency Genetic Variation/genetics Genome, Human Genomics/methods Haplotypes/genetics Humans International Cooperation Polymorphism, Single Nucleotide/genetics Public Sector Racial Groups/genetics
Chemicals
DNA
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
International HapMap Consortium
Article Info
Journal
Nature
Abbr.
Nature
ISSN
1476-4687
Published
2003-12-18
Pages
789-96
Language
English
Region
England
NLM ID
0410462
Subset
IM
Corrections
CommentIn
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