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PMID: 20813250 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Phosphotyrosine signaling: evolving a new cellular communication system.

Cell ·Vol. 142 ·No. 5 ·2010-09-03 ·Pages 661-7

Lim WA, Pawson T

Abstract

Tyrosine phosphorylation controls many cellular functions. Yet the three-part toolkit that regulates phosphotyrosine signaling-tyrosine kinases, phosphotyrosine phosphatases, and Src Homology 2 (SH2) domains-is a relatively new innovation. Genomic analyses reveal how this revolutionary signaling system may have originated and why it rapidly became critical to metazoans.

MeSH Terms
Animals Choanoflagellata/genetics,metabolism Evolution, Molecular Phosphotyrosine/metabolism Protein-Tyrosine Kinases/metabolism Signal Transduction
Chemicals
Phosphotyrosine Protein-Tyrosine Kinases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Lim Wendell A
Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94158, USA. lim@cmp.ucsf.edu
Pawson Tony
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Article Info
Journal
Cell
Abbr.
Cell
ISSN
1097-4172
DOI
10.1016/j.cell.2010.08.023
Email
lim@cmp.ucsf.edu
Published
2010-09-03
Pages
661-7
Language
English
Region
United States
NLM ID
0413066
PMCID
PMC2950826
Subset
IM
Grants
NIGMS NIH HHS · R01 GM062583-08 · United States
NIGMS NIH HHS · P50 GM081879-01A2 · United States
NEI NIH HHS · PN2 EY016546-06 · United States
NIGMS NIH HHS · GM081879 · United States
NIGMS NIH HHS · GM55040 · United States
NIGMS NIH HHS · P50 GM081879 · United States
NIGMS NIH HHS · R01 GM055040 · United States
Howard Hughes Medical Institute · United States
NIGMS NIH HHS · GM62583 · United States
NEI NIH HHS · PN2 EY016546 · United States
NIGMS NIH HHS · R01 GM055040-12 · United States
NEI NIH HHS · EY016546 · United States
CIHR · -MOP-6849 · Canada
NEI NIH HHS · PN1 EY016546 · United States
NIGMS NIH HHS · R01 GM062583 · United States
External Links
PubMed source DOI: 10.1016/j.cell.2010.08.023 PMC Full Text View journal details
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