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PMID: 20732639 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Interleukin-2 receptor signaling: at the interface between tolerance and immunity.

Immunity ·Vol. 33 ·No. 2 ·2010-08-27 ·Pages 153-65

Malek TR, Castro I

Abstract

Interleukin-2 receptor (IL-2R) signaling regulates tolerance and immunity. Here, we review recent work concerning the structure, signaling, and function of the IL-2R, emphasizing the contribution of IL-2 for T cell-dependent activity in vivo. IL-2R signaling influences two discrete aspects of immune responses by CD8(+) T cells, terminal differentiation of effector cells in primary responses, and aspects of memory recall responses. IL-2 also delivers essential signals for thymic development of regulatory T (Treg) cells and later to promote their homeostasis and function. Each of these outcomes on T effector and Treg cells requires distinct amounts of IL-2R signaling, with low IL-2R signaling sufficient for many key aspects of Treg cells. Thus, tolerance is readily maintained and favored with limited IL-2.

MeSH Terms
Animals Humans Immune Tolerance Immunity Immunologic Memory Receptors, Interleukin-2/immunology,metabolism Signal Transduction T-Lymphocytes/cytology,immunology
Chemicals
Receptors, Interleukin-2
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Malek Thomas R
Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, PO Box 01960, Miami, FL 33101, USA. tmalek@med.miami.edu
Castro Iris
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Article Info
Journal
Immunity
Abbr.
Immunity
ISSN
1097-4180
DOI
10.1016/j.immuni.2010.08.004
Email
tmalek@med.miami.edu
Published
2010-08-27
Pages
153-65
Language
English
Region
United States
NLM ID
9432918
PMCID
PMC2946796
Subset
IM
Grants
NCI NIH HHS · R01CA45957 · United States
NIAID NIH HHS · R01 AI055815 · United States
NIAID NIH HHS · 3R56AI40114 · United States
NCI NIH HHS · R01 CA045957 · United States
NIAID NIH HHS · R01 AI055815-05 · United States
NCI NIH HHS · P01 CA109094 · United States
NIAID NIH HHS · R56 AI040114 · United States
NIAID NIH HHS · R01AI055815 · United States
NIAID NIH HHS · R56 AI040114-11A1S1 · United States
NCI NIH HHS · R01 CA045957-23 · United States
NCI NIH HHS · P01 CA109094-040001 · United States
NCI NIH HHS · P01CA109094 · United States
External Links
PubMed source DOI: 10.1016/j.immuni.2010.08.004 PMC Full Text View journal details
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