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PMID: 20708398 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

VE-cadherin: at the front, center, and sides of endothelial cell organization and function.

Current opinion in cell biology ·Vol. 22 ·No. 5 ·2010-10-00 ·Pages 651-8

Harris ES, Nelson WJ

Abstract

Endothelial cells form cell-cell adhesive structures, called adherens and tight junctions, which maintain tissue integrity, but must be dynamic for leukocyte transmigration during the inflammatory response and cellular remodeling during angiogenesis. This review will focus on Vascular Endothelial (VE)-cadherin, an endothelial-specific cell-cell adhesion protein of the adherens junction complex. VE-cadherin plays a key role in endothelial barrier function and angiogenesis, and consequently VE-cadherin availability and function are tightly regulated. VE-cadherin also participates directly and indirectly in intracellular signaling pathways that control cell dynamics and cell cycle progression. Here we highlight recent work that has advanced our understanding of multiple regulatory and signaling mechanisms that converge on VE-cadherin and have consequences for endothelial barrier function and angiogenic remodeling.

MeSH Terms
Animals Antigens, CD/metabolism Cadherins/metabolism Cell-Matrix Junctions Endothelial Cells Humans Neovascularization, Physiologic
Chemicals
Antigens, CD Cadherins cadherin 5
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Harris Elizabeth S
Department of Biology, The James H. Clark Center, Bio-X Program, Stanford University, Stanford, CA 94305, USA. eharris1@stanford.edu
Nelson W James
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Article Info
Journal
Current opinion in cell biology
Abbr.
Curr Opin Cell Biol
ISSN
1879-0410
DOI
10.1016/j.ceb.2010.07.006
Email
eharris1@stanford.edu
Published
2010-10-00
Epub
2010-00-11
Pages
651-8
Language
English
Region
England
NLM ID
8913428
PMCID
PMC2948582
Subset
IM
Grants
NIGMS NIH HHS · R01 GM035527 · United States
NIGMS NIH HHS · R37 GM035527 · United States
NIGMS NIH HHS · GM035527 · United States
External Links
PubMed source DOI: 10.1016/j.ceb.2010.07.006 PMC Full Text View journal details
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