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PMID: 17961505 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Endothelial adherens and tight junctions in vascular homeostasis, inflammation and angiogenesis.

Biochimica et biophysica acta ·Vol. 1778 ·No. 3 ·2008-03-00 ·Pages 794-809

Wallez Y, Huber P

Abstract

Endothelial cells lining the vessel wall are connected by adherens, tight and gap junctions. These junctional complexes are related to those found at epithelial junctions but with notable changes in terms of specific molecules and organization. Endothelial junctional proteins play important roles in tissue integrity but also in vascular permeability, leukocyte extravasation and angiogenesis. In this review, we will focus on specific mechanisms of endothelial tight and adherens junctions.

MeSH Terms
Adherens Junctions/physiology,ultrastructure Animals Antigens, CD/chemistry,physiology Cadherins/chemistry,physiology Cell Adhesion Molecules/chemistry,physiology Cell Proliferation Contact Inhibition Endothelial Cells/physiology,ultrastructure Homeostasis Humans Inflammation/pathology,physiopathology Membrane Proteins/chemistry,physiology Models, Biological Models, Molecular Multiprotein Complexes Neovascularization, Physiologic Signal Transduction Tight Junctions/physiology,ultrastructure beta Catenin/chemistry,physiology
Chemicals
Antigens, CD Cadherins Cell Adhesion Molecules Membrane Proteins Multiprotein Complexes beta Catenin cadherin 5
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Wallez Yann
Vascular Pathophysiology Laboratory, Inserm U882 38054 Grenoble, France.
Huber Philippe
Article Info
Journal
Biochimica et biophysica acta
Abbr.
Biochim Biophys Acta
ISSN
0006-3002
DOI
10.1016/j.bbamem.2007.09.003
Published
2008-03-00
Epub
2007-00-15
Pages
794-809
Language
English
Region
Netherlands
NLM ID
0217513
Subset
IM
External Links
PubMed source DOI: 10.1016/j.bbamem.2007.09.003
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