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PMID: 20678910 Published · ppublish English Journal Article Review

Regulated protein kinases and phosphatases in cell cycle decisions.

Current opinion in cell biology ·Vol. 22 ·No. 6 ·2010-12-00 ·Pages 801-8

Novak B, Kapuy O, Domingo-Sananes MR, Tyson JJ

Abstract

Many aspects of cell physiology are controlled by protein kinases and phosphatases, which together determine the phosphorylation state of targeted substrates. Some of these target proteins are themselves kinases or phosphatases or other components of a regulatory network characterized by feedback and feed-forward loops. In this review we describe some common regulatory motifs involving kinases, phosphatases, and their substrates, focusing particularly on bistable switches involved in cellular decision processes. These general principles are applied to cell cycle transitions, with special emphasis on the roles of regulated phosphatases in orchestrating progression from one phase to the next of the DNA replication-division cycle.

MeSH Terms
Biological Evolution Cell Cycle/physiology Feedback, Physiological Phosphoric Monoester Hydrolases/genetics,metabolism Phosphorylation Protein Kinases/genetics,metabolism
Chemicals
Protein Kinases Phosphoric Monoester Hydrolases
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Novak Bela
Centre for Integrative Systems Biology and Department of Biochemistry, Oxford University, Oxford, UK. bela.novak@bioch.ox.ac.uk
Kapuy Orsolya
Domingo-Sananes Maria Rosa
Tyson John J
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Article Info
Journal
Current opinion in cell biology
Abbr.
Curr Opin Cell Biol
ISSN
1879-0410
DOI
10.1016/j.ceb.2010.07.001
Email
bela.novak@bioch.ox.ac.uk
Published
2010-12-00
Epub
2010-00-02
Pages
801-8
Language
English
Region
England
NLM ID
8913428
PMCID
PMC3769698
Subset
IM
Grants
NIGMS NIH HHS · R01 GM078989 · United States
External Links
PubMed source DOI: 10.1016/j.ceb.2010.07.001 PMC Full Text View journal details
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