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PMID: 2060518 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Antistaphylococcal activity of the fluoroquinolones CI-960, PD 131628, sparfloxacin, ofloxacin and ciprofloxacin.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology ·Vol. 10 ·No. 3 ·1991-03-00 ·Pages 168-71

Barry AL, Fuchs PC

Abstract

Five fluoroquinolones were tested against 300 staphylococci from a wide variety of US medical centers including 150 strains resistant to penicillinase-resistant penicillins (PRP-resistant). Ten ciprofloxacin-resistant strains of PRP-resistant Staphylococcus aureus were relatively resistant to the other fluoroquinolones, but the remaining 290 isolates were susceptible to all five drugs at established or anticipated breakpoint concentrations. The relative potency of the study drugs could be ranked as follows: CI-960 greater than PD 131628 greater than sparfloxacin greater than ciprofloxacin greater than ofloxacin. All five drugs were bactericidal against PRP-resistant and PRP-susceptible staphylococci.

MeSH Terms

Anti-Infective Agents/pharmacology Ciprofloxacin/pharmacology Drug Resistance, Microbial Fluoroquinolones Microbial Sensitivity Tests Naphthyridines Ofloxacin/pharmacology Penicillin Resistance Staphylococcus/drug effects Staphylococcus aureus/drug effects

Chemicals

Anti-Infective Agents Fluoroquinolones Naphthyridines PD 131628 Ciprofloxacin clinafloxacin Ofloxacin sparfloxacin

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Barry A L

Clinical Microbiology Institute, Tualatin, Oregon 97062.

Fuchs P C

References (9)

9 references, click to expand

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Article Info

Journal

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

Abbr.

Eur J Clin Microbiol Infect Dis

ISSN

0934-9723

DOI

10.1007/BF01964451

Published

1991-03-00

Pages

168-71

Language

English

Region

Germany

NLM ID

8804297

Subset

External Links

PubMed source DOI: 10.1007/BF01964451 View journal details

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Antistaphylococcal activity of the fluoroquinolones CI-960, PD 131628, sparfloxacin, ofloxacin and ciprofloxacin.

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