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PMID: 3142352 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Comparative in vitro activity of PD 127,391, a new fluorinated 4-quinolone derivative.

Antimicrobial agents and chemotherapy ·Vol. 32 ·No. 8 ·1988-08-00 ·Pages 1278-81

Norrby SR, Jonsson M

Abstract

PD 127,391, a newly developed 4-quinolone chemically similar to ciprofloxacin, was studied in vitro by using agar and broth dilution and two inoculum sizes. PD 127,391 was found to be highly active against gram-negative aerobes, including Pseudomonas aeruginosa and other Pseudomonas spp. Its activity against gram-positive aerobes was better than that of ciprofloxacin.

MeSH Terms
Anti-Infective Agents/pharmacology Bacteria, Aerobic/drug effects Ceftazidime/pharmacology Chemical Phenomena Chemistry Ciprofloxacin/pharmacology Fluoroquinolones Gentamicins/pharmacology Gram-Negative Aerobic Bacteria/drug effects Humans Imipenem/pharmacology Microbial Sensitivity Tests Pseudomonas aeruginosa/drug effects
Chemicals
Anti-Infective Agents Fluoroquinolones Gentamicins Ciprofloxacin Imipenem clinafloxacin Ceftazidime
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Norrby S R
Department of Infectious Diseases, University of Umeå, Sweden.
Jonsson M
References (4)
4 references, click to expand
  1. Review of in vitro activity of third-generation cephalosporins and other newer beta-lactam antibiotics against clinically important bacteria.
    Am J Med. 1985 Aug 9;79(2A):14-20 PMID: 3927723
  2. Quinolone antibacterial agents. Synthesis and structure-activity relationships of 8-substituted quinoline-3-carboxylic acids and 1,8-naphthyridine-3-carboxylic acids.
    J Med Chem. 1988 May;31(5):983-91 PMID: 3361584
  3. The comparative in-vitro activity of eight newer quinolones and nalidixic acid.
    J Antimicrob Chemother. 1986 Nov;18 Suppl D:1-20 PMID: 3468100
  4. Antibacterial activity of imipenem: the first thienamycin antibiotic.
    Rev Infect Dis. 1985 Jul-Aug;7 Suppl 3:S389-410 PMID: 3931196
Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.32.8.1278
Published
1988-08-00
Pages
1278-81
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC172394
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.32.8.1278 PMC Full Text View journal details
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