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PMID: 20560908 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

TSLP polymorphisms are associated with asthma in a sex-specific fashion.

Allergy ·Vol. 65 ·No. 12 ·2010-12-00 ·Pages 1566-75

Hunninghake GM, Soto-Quirós ME, Avila L, Kim HP, Lasky-Su J, Rafaels N, Ruczinski I, Beaty TH, Mathias RA, Barnes KC, Wilk JB, O'Connor GT, Gauderman WJ, Vora H, Baurley JW, Gilliland F, Liang C, Sylvia JS, Klanderman BJ, Sharma SS, Himes BE, Bossley CJ, Israel E, Raby BA, Bush A, Choi AM, Weiss ST, Celedón JC

Abstract

Single nucleotide polymorphisms (SNPs) in thymic stromal lymphopoietin (TSLP) have been associated with IgE (in girls) and asthma (in general). We sought to determine whether TSLP SNPs are associated with asthma in a sex-specific fashion. We conducted regular and sex-stratified analyses of association between SNPs in TSLP and asthma in families of children with asthma in Costa Rica. Significant findings were replicated in whites and African-American participants in the Childhood Asthma Management Program, in African-Americans in the Genomic Research on Asthma in the African Diaspora study, in whites and Hispanics in the Children's Health Study, and in whites in the Framingham Heart Study (FHS). Two SNPs in TSLP (rs1837253 and rs2289276) were significantly associated with a reduced risk of asthma in combined analyses of all cohorts (P values of 2 × 10(-5) and 1 × 10(-5) , respectively). In a sex-stratified analysis, the T allele of rs1837253 was significantly associated with a reduced risk of asthma in males only (P = 3 × 10(-6) ). Alternately, the T allele of rs2289276 was significantly associated with a reduced risk of asthma in females only (P = 2 × 10(-4) ). Findings for rs2289276 were consistent in all cohorts except the FHS. TSLP variants are associated with asthma in a sex-specific fashion.

MeSH Terms
Asthma/genetics Blacks/genetics Child Cohort Studies Costa Rica Cytokines/genetics Female Genetic Predisposition to Disease/ethnology,genetics Genome-Wide Association Study Genotype Hispanic or Latino/genetics Humans Male Polymorphism, Single Nucleotide Risk Factors Sex Characteristics Whites/genetics
Chemicals
Cytokines thymic stromal lymphopoietin
Authors & Affiliations
28 authors, click to expand affiliations / ORCID
Hunninghake G M
Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Soto-Quirós M E
Avila L
Kim H P
Lasky-Su J
Rafaels N
Ruczinski I
Beaty T H
Mathias R A
Barnes K C
Wilk J B
O'Connor G T
Gauderman W James
Vora H
Baurley J W
Gilliland F
Liang C
Sylvia J S
Klanderman B J
Sharma S S
Himes B E
Bossley C J
Israel E
Raby B A
Bush A
Choi A M
Weiss S T
Celedón J C
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Article Info
Journal
Allergy
Abbr.
Allergy
ISSN
1398-9995
DOI
10.1111/j.1398-9995.2010.02415.x
Published
2010-12-00
Pages
1566-75
Language
English
Region
Denmark
NLM ID
7804028
PMCID
PMC2970693
Subset
IM
Grants
NIEHS NIH HHS · P01 ES011627-010003 · United States
NHLBI NIH HHS · R01 HL087699-01 · United States
NHLBI NIH HHS · N01 HC025195 · United States
NHLBI NIH HHS · U01 HL065899 · United States
NHLBI NIH HHS · R01 HL086601-01 · United States
NHLBI NIH HHS · R01 HL087699 · United States
NHLBI NIH HHS · K01 HL004370-02 · United States
NHLBI NIH HHS · U01 HL075419 · United States
NHLBI NIH HHS · K12 HL089990 · United States
NHLBI NIH HHS · U01 HL075419-01 · United States
NHLBI NIH HHS · T32 HL07427 · United States
NHLBI NIH HHS · T32 HL007427 · United States
NIEHS NIH HHS · P30 ES007048 · United States
NHLBI NIH HHS · P01 HL083069 · United States
NHLBI NIH HHS · R00 HL096840 · United States
NHLBI NIH HHS · K01 HL004370 · United States
NHLBI NIH HHS · U01 HL65899 · United States
NHLBI NIH HHS · K08HL092222 · United States
NLM NIH HHS · T15 LM007092 · United States
NHLBI NIH HHS · R37 HL066289 · United States
NHLBI NIH HHS · R01 HL087680-01 · United States
NHLBI NIH HHS · R01 HL066289-01 · United States
NIEHS NIH HHS · P01 ES011627 · United States
NHLBI NIH HHS · K08 HL092222-03 · United States
NHLBI NIH HHS · R01 HL087680 · United States
NHLBI NIH HHS · K08 HL092222 · United States
NHLBI NIH HHS · T32 HL007427-19 · United States
NHLBI NIH HHS · P01 HL083069-02 · United States
NHLBI NIH HHS · K08 HL096833 · United States
NHLBI NIH HHS · HL04370 · United States
NHLBI NIH HHS · HL66289 · United States
NHLBI NIH HHS · R01 HL066289 · United States
NHLBI NIH HHS · N01HC25195 · United States
NHLBI NIH HHS · U01 HL065899-01 · United States
NHLBI NIH HHS · R01 HL086601 · United States
NHLBI NIH HHS · N01-HC25195 · United States
NIEHS NIH HHS · P30 ES007048-04S19001 · United States
NLM NIH HHS · 2T15LM007092-16 · United States
External Links
PubMed source DOI: 10.1111/j.1398-9995.2010.02415.x PMC Full Text View journal details
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