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PMID: 2052575 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Expression of type I and type II bovine scavenger receptors in Chinese hamster ovary cells: lipid droplet accumulation and nonreciprocal cross competition by acetylated and oxidized low density lipoprotein.

Freeman M, Ekkel Y, Rohrer L, Penman M, Freedman NJ, Chisolm GM, Krieger M

Abstract

Type I and type II scavenger receptors, which have been implicated in the development of atherosclerosis and other macrophage-associated functions, differ only by the presence in the type I receptor of an extracellular cysteine-rich C-terminal domain. Stable Chinese hamster ovary (CHO) cell transfectants expressing high levels of either the type I or type II bovine scavenger receptors have been generated. Type I and type II receptors in these cells mediated high-affinity saturable endocytosis of both 125I-labeled acetylated low density lipoprotein (LDL) and 125I-labeled oxidized LDL with the distinctive broad ligand specificity characteristic of scavenger receptors. After incubation for 2 days with acetylated LDL, the transfected cells accumulated oil red O-staining lipid droplets reminiscent of those in macrophage foam cells, whereas untransfected CHO cells did not. Thus, macrophage-specific gene products other than the scavenger receptor are not required for modified-LDL-induced intracellular lipid accumulation. In transfected cells, acetylated LDL efficiently competed for both its own endocytosis and that of oxidized LDL. In contrast, oxidized LDL competed effectively for its own endocytosis but only poorly for that of acetylated LDL. This nonreciprocal cross competition suggests that these ligands may bind to nonidentical but interacting sites on a single receptor. Results were similar for transfectants expressing either type I or type II scavenger receptors. Therefore, the nonreciprocal cross competition previously reported for cultured peritoneal macrophages may not be the result of differences between the type I and type II receptors. The nonreciprocal cross competition seen in the transfected CHO cells differs from that previously observed with cultured macrophages.

MeSH Terms
Acetylation Animals Binding, Competitive Cattle Cell Line Cricetinae Cricetulus Female Kinetics Lipid Metabolism Lipoproteins, LDL/metabolism Membrane Proteins Ovary Oxidation-Reduction Receptors, Immunologic/genetics,physiology Receptors, Lipoprotein Receptors, Scavenger Scavenger Receptors, Class B Transfection
Chemicals
Lipoproteins, LDL Membrane Proteins Receptors, Immunologic Receptors, Lipoprotein Receptors, Scavenger Scarb1 protein, mouse Scavenger Receptors, Class B
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Freeman M
Department of Biology, Massachusetts Institute of Technology, Cambridge 02139.
Ekkel Y
Rohrer L
Penman M
Freedman N J
Chisolm G M
Krieger M
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
Published
1991-06-01
Pages
4931-5
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC51781
Subset
IM
Grants
NHLBI NIH HHS · HL29582 · United States
NHLBI NIH HHS · HL41484 · United States
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