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PMID: 20521089 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Review

Epithelial mesenchymal transition traits in human breast cancer cell lines parallel the CD44(hi/)CD24 (lo/-) stem cell phenotype in human breast cancer.

Journal of mammary gland biology and neoplasia ·Vol. 15 ·No. 2 ·2010-06-00 ·Pages 235-52

Blick T, Hugo H, Widodo E, Waltham M, Pinto C, Mani SA, Weinberg RA, Neve RM, Lenburg ME, Thompson EW

Abstract

We review here the recently emerging relationship between epithelial-mesenchymal transition (EMT) and breast cancer stem cells (BCSC), and provide analyses of published data on human breast cancer cell lines, supporting their utility as a model for the EMT/BCSC state. Genome-wide transcriptional profiling of these cell lines has confirmed the existence of a subgroup with mesenchymal tendencies and enhanced invasive properties ('Basal B'/Mesenchymal), distinct from subgroups with either predominantly luminal ('Luminal') or mixed basal/luminal ('Basal A') features (Neve et al. Cancer Cell, 2006). A literature-derived EMT gene signature has shown specific enrichment within the Basal B subgroup of cell lines, consistent with their over-expression of various EMT transcriptional drivers. Basal B cell lines are found to resemble BCSC, being CD44(high)CD24(low). Moreover, gene products that distinguish Basal B from Basal A and Luminal cell lines (Basal B Discriminators) showed close concordance with those that define BCSC isolated from clinical material, as reported by Shipitsin et al. (Cancer Cell, 2007). CD24 mRNA levels varied across Basal B cell lines, correlating with other Basal B Discriminators. Many gene products correlating with CD24 status in Basal B cell lines were also differentially expressed in isolated BCSC. These findings confirm and extend the importance of the cellular product of the EMT with Basal B cell lines, and illustrate the value of analysing these cell lines for new leads that may improve breast cancer outcomes. Gene products specific to Basal B cell lines may serve as tools for the detection, quantification, and analysis of BCSC/EMT attributes.

MeSH Terms
Antineoplastic Agents/pharmacology,therapeutic use Breast Neoplasms/drug therapy,metabolism,physiopathology CD24 Antigen/metabolism Cell Dedifferentiation Cell Line, Tumor Cell Transdifferentiation Epithelial Cells/physiology Female Humans Hyaluronan Receptors/metabolism Mesenchymal Stem Cells/drug effects,physiology Neoplastic Stem Cells/drug effects,physiology Phenotype
Chemicals
Antineoplastic Agents CD24 Antigen CD24 protein, human CD44 protein, human Hyaluronan Receptors
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Blick Tony
Invasion and Metastasis Unit, St. Vincent's Institute, 9 Princes St, Fitzroy, Melbourne 3065, Australia.
Hugo Honor
Widodo Edwin
Waltham Mark
Pinto Cletus
Mani Sendurai A
Weinberg Robert A
Neve Richard M
Lenburg Marc E
Thompson Erik W
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Article Info
Journal
Journal of mammary gland biology and neoplasia
Abbr.
J Mammary Gland Biol Neoplasia
ISSN
1573-7039
DOI
10.1007/s10911-010-9175-z
Published
2010-06-00
Epub
2010-00-04
Pages
235-52
Language
English
Region
United States
NLM ID
9601804
Subset
IM
External Links
PubMed source DOI: 10.1007/s10911-010-9175-z View journal details
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