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PMID: 15339045 Published · ppublish English Journal Article Review

Tumour biological aspects of CD24, a mucin-like adhesion molecule.

Journal of molecular histology ·Vol. 35 ·No. 3 ·2004-03-00 ·Pages 255-62

Kristiansen G, Sammar M, Altevogt P

Abstract

CD24 is a molecule that recently has raised considerable attention in tumour biology. It is involved in cell adhesion and metastatic tumour spread. It has also been described as a new diagnostic marker of tumours, of neuroendocrine differentiation and, possibly most intriguing of all, of patient prognosis. High rates of CD24 expression detected by immunohistochemistry have been found in epithelial ovarian cancer (83%), breast cancer (85%), non-small cell lung cancer (45%), prostate cancer (48%) and pancreatic cancer (72%). With the exception of pancreatic cancer, high rates of CD24 are significantly associated with a more aggressive course of the disease, a finding that remains significant in a multivariate analysis. The aim of this review is to summarize relevant work covering these aspects of CD24.

MeSH Terms
Amino Acid Sequence Animals Antigens, CD/metabolism Biomarkers, Tumor/metabolism CD24 Antigen Cell Adhesion Cell Adhesion Molecules/metabolism Female Humans Immunohistochemistry Male Membrane Glycoproteins/metabolism Molecular Sequence Data Mucins/metabolism Neoplasm Metastasis Neoplasms/metabolism,pathology Prognosis
Chemicals
Antigens, CD Biomarkers, Tumor CD24 Antigen CD24 protein, human Cell Adhesion Molecules Membrane Glycoproteins Mucins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Kristiansen G
Institute of Pathology, Charité University Hospital, Schumannstrasse 20/21, 10117 Berlin, Germany.
Sammar M
Altevogt P
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Article Info
Journal
Journal of molecular histology
Abbr.
J Mol Histol
ISSN
1567-2379
DOI
10.1023/b:hijo.0000032357.16261.c5
Published
2004-03-00
Pages
255-62
Language
English
Region
Netherlands
NLM ID
101193653
Subset
IM
External Links
PubMed source DOI: 10.1023/b:hijo.0000032357.16261.c5 View journal details
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