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PMID: 20395969 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Genome-wide association studies in diverse populations.

Nature reviews. Genetics ·Vol. 11 ·No. 5 ·2010-05-00 ·Pages 356-66

Rosenberg NA, Huang L, Jewett EM, Szpiech ZA, Jankovic I, Boehnke M

Abstract

Genome-wide association (GWA) studies have identified a large number of SNPs associated with disease phenotypes. As most GWA studies have been performed in populations of European descent, this Review examines the issues involved in extending the consideration of GWA studies to diverse worldwide populations. Although challenges exist with issues such as imputation, admixture and replication, investigation of a greater diversity of populations could make substantial contributions to the goal of mapping the genetic determinants of complex diseases for the human population as a whole.

MeSH Terms
Genetics, Population Genome, Human Genome-Wide Association Study Humans
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Rosenberg Noah A
Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA. rnoah@umich.edu
Huang Lucy
Jewett Ethan M
Szpiech Zachary A
Jankovic Ivana
Boehnke Michael
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Article Info
Journal
Nature reviews. Genetics
Abbr.
Nat Rev Genet
ISSN
1471-0064
DOI
10.1038/nrg2760
Email
rnoah@umich.edu
Published
2010-05-00
Pages
356-66
Language
English
Region
England
NLM ID
100962779
PMCID
PMC3079573
Subset
IM
Grants
NIDDK NIH HHS · R56 DK062370 · United States
NHGRI NIH HHS · R01 HG000376 · United States
NHGRI NIH HHS · T32 HG000040 · United States
NHGRI NIH HHS · R56 HG000376 · United States
NIDDK NIH HHS · R01 DK062370 · United States
NHLBI NIH HHS · HL090564 · United States
NIDDK NIH HHS · U01 DK062370 · United States
NIGMS NIH HHS · R01 GM081441-04 · United States
NHGRI NIH HHS · HG000376 · United States
NHLBI NIH HHS · R01 HL090564 · United States
NIGMS NIH HHS · R01 GM081441 · United States
NIDDK NIH HHS · DK062370 · United States
NIGMS NIH HHS · GM081441 · United States
External Links
PubMed source DOI: 10.1038/nrg2760 PMC Full Text View journal details
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