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PMID: 20395010 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Molecular diversity through RNA editing: a balancing act.

Trends in genetics : TIG ·Vol. 26 ·No. 5 ·2010-05-00 ·Pages 221-30

Farajollahi S, Maas S

Abstract

RNA editing by adenosine deamination fuels the generation of RNA and protein diversity in eukaryotes, particularly in higher organisms. This includes the recoding of translated exons, widespread editing of retrotransposon-derived repeat elements and sequence modification of microRNA (miRNA) transcripts. Such changes can bring about specific amino acid substitutions, alternative splicing and changes in gene expression levels. Although the overall prevalence of adenosine-to-inosine (A-to-I) editing and its specific functional impact on many of the affected genes is not yet known, the importance of balancing RNA modification levels across time and space is becoming increasingly evident. In particular, transcriptome instabilities in the form of too much or too little RNA editing activity, or misguided editing, manifest in several human disease phenotypes and can disrupt that balance.

MeSH Terms
Adenosine/metabolism Animals Deamination Humans Neoplasms/genetics Nervous System Diseases/genetics Proteins/genetics RNA Editing
Chemicals
Proteins Adenosine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Farajollahi Sanaz
Department of Biological Sciences, Lehigh University, Bethlehem, PA 18015, USA.
Maas Stefan
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Article Info
Journal
Trends in genetics : TIG
Abbr.
Trends Genet
ISSN
0168-9525
DOI
10.1016/j.tig.2010.02.001
Published
2010-05-00
Epub
2010-00-13
Pages
221-30
Language
English
Region
England
NLM ID
8507085
PMCID
PMC2865426
Subset
IM
Grants
NINDS NIH HHS · R15 NS057739 · United States
NINDS NIH HHS · R15 NS057739-01A1 · United States
NINDS NIH HHS · NS057739 · United States
External Links
PubMed source DOI: 10.1016/j.tig.2010.02.001 PMC Full Text View journal details
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