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PMID: 20373666 Published · ppublish English Journal Article

Personal genomes in progress: from the human genome project to the personal genome project.

Dialogues in clinical neuroscience ·Vol. 12 ·No. 1 ·2010-00-00 ·Pages 47-60

Lunshof JE, Bobe J, Aach J, Angrist M, Thakuria JV, Vorhaus DB, Hoehe MR, Church GM

Abstract

The cost of a diploid human genome sequence has dropped from about $70M to $2000 since 2007--even as the standards for redundancy have increased from 7x to 40x in order to improve call rates. Coupled with the low return on investment for common single-nucleotide polylmorphisms, this has caused a significant rise in interest in correlating genome sequences with comprehensive environmental and trait data (GET). The cost of electronic health records, imaging, and microbial, immunological, and behavioral data are also dropping quickly. Sharing such integrated GET datasets and their interpretations with a diversity of researchers and research subjects highlights the need for informed-consent models capable of addressing novel privacy and other issues, as well as for flexible data-sharing resources that make materials and data available with minimum restrictions on use. This article examines the Personal Genome Project's effort to develop a GET database as a public genomics resource broadly accessible to both researchers and research participants, while pursuing the highest standards in research ethics.

MeSH Terms
Computational Biology/methods Databases, Genetic/economics,statistics & numerical data Electronic Health Records/economics,statistics & numerical data Environment Genetic Privacy Genome, Human/physiology Human Genome Project/economics Humans
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Lunshof Jeantine E
European Centre for Public Health Genomics, FHML, Maastricht University, Maastricht, The Netherlands.
Bobe Jason
Aach John
Angrist Misha
Thakuria Joseph V
Vorhaus Daniel B
Hoehe Margret R
Church George M
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Article Info
Journal
Dialogues in clinical neuroscience
Abbr.
Dialogues Clin Neurosci
ISSN
1294-8322
Published
2010-00-00
Pages
47-60
Language
English
Region
France
NLM ID
101238198
PMCID
PMC3181947
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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