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PMID: 2037352 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Characterization of the protective antibody response to Borrelia burgdorferi in experimentally infected LSH hamsters.

Infection and immunity ·Vol. 59 ·No. 6 ·1991-06-00 ·Pages 1916-21

Schmitz JL, Schell RF, Lovrich SD, Callister SM, Coe JE

Abstract

We show that serum obtained from normal hamsters infected with Borrelia burgdorferi can confer complete protection on irradiated recipients challenged with the Lyme spirochete. Borreliacidal activity was detected 7 days after infection, peaked at weeks 3 to 5, and thereafter decreased. Relatively high borreliacidal activity was detected in immune serum at weeks 3 and 5 of infection. The borreliacidal activity did not correlate with antibody used for the serodiagnosis of Lyme disease, which remained elevated throughout experimental infection. Our results also demonstrated that blocking antibody and antigenic variation in B. burgdorferi did not account for the decreasing titer of protective antibody. These findings indicate that protection against reinfection gradually wanes.

MeSH Terms
Animals Antibodies, Bacterial/analysis Blotting, Western Borrelia burgdorferi Group/growth & development,immunology Cricetinae Disease Models, Animal Electrophoresis, Polyacrylamide Gel Enzyme-Linked Immunosorbent Assay Immunoglobulin G/analysis Immunoglobulin M/analysis Lyme Disease/immunology,prevention & control
Chemicals
Antibodies, Bacterial Immunoglobulin G Immunoglobulin M
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Schmitz J L
Wisconsin State Laboratory of Hygiene, University of Wisconsin, Madison 53706.
Schell R F
Lovrich S D
Callister S M
Coe J E
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.59.6.1916-1921.1991
Published
1991-06-00
Pages
1916-21
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC257943
Subset
IM
Grants
NIAID NIH HHS · AI-22199 · United States
External Links
PubMed source DOI: 10.1128/iai.59.6.1916-1921.1991 PMC Full Text View journal details
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