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PMID: 20371823 Published · ppublish English Comparative Study Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Distinct functions of acj6 splice forms in odor receptor gene choice.

Bai L, Carlson JR

Abstract

Individual olfactory receptor neurons (ORNs) selectively express one or a small number of odor receptors from among a large receptor repertoire. The expression of an odor receptor dictates the odor response spectrum of the ORN. The process of receptor gene choice relies in part on a combinatorial code of transcription factors. In Drosophila, the POU domain transcription factor Acj6 is one element of the transcription factor code. In acj6 null mutants, many ORNs do not express an appropriate odor receptor gene and thus are not correctly specified. We find that acj6 is alternatively spliced to yield many structurally distinct transcripts in the olfactory organs. We generate flies that express single splice forms of acj6 in an acj6(-) background. We find that different splice forms are functionally distinct; they differ in their abilities to specify ORN identities. Some individual splice forms can fully rescue the specification of some ORNs. Individual splice forms can function both positively and negatively in receptor gene regulation. ORNs differ in their requirements for splice forms; some are not fully rescued by any single splice form tested, suggesting that some ORNs may require the combinatorial action of multiple splice forms. Late expression of some acj6 splice forms is sufficient to rescue some ORN classes, consistent with a direct role for Acj6 isoforms in receptor gene expression. The results indicate that alternative splicing may add another level of richness to the regulatory code that underlies the process of odor receptor gene choice.

MeSH Terms
Alternative Splicing/genetics,physiology Amino Acid Sequence Animals Animals, Genetically Modified Drosophila Proteins/biosynthesis,deficiency,genetics,physiology Drosophila melanogaster/genetics Gene Knockout Techniques Larva/genetics,physiology Molecular Sequence Data Nerve Tissue Proteins/deficiency,genetics,physiology Olfactory Receptor Neurons/physiology POU Domain Factors/deficiency,genetics,physiology Protein Isoforms/deficiency,genetics,physiology Receptors, Odorant/biosynthesis,deficiency,genetics
Chemicals
Drosophila Proteins Nerve Tissue Proteins POU Domain Factors Protein Isoforms Receptors, Odorant acj6 protein, Drosophila
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Bai Lei
Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA.
Carlson John R
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Article Info
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
Abbr.
J Neurosci
ISSN
1529-2401
Published
2010-04-07
Pages
5028-36
Language
English
Region
United States
NLM ID
8102140
PMCID
PMC2858447
Subset
IM
Grants
NIGMS NIH HHS · R01 GM063364-06 · United States
NIDCD NIH HHS · R01 DC004729-10 · United States
NIDCD NIH HHS · R01 DC002174-19 · United States
NIDCD NIH HHS · R01 DC002174-18A1 · United States
NIDCD NIH HHS · R01 DC002174-22 · United States
NIGMS NIH HHS · R01 GM063364 · United States
NIDCD NIH HHS · R01 DC004729-09 · United States
NIDCD NIH HHS · R01 DC002174-21 · United States
NIDCD NIH HHS · R01 DC002174-17 · United States
NIDCD NIH HHS · R01 DC002174-20 · United States
NIDCD NIH HHS · R01 DC002174-23 · United States
NIDCD NIH HHS · R01 DC004729-08 · United States
NIGMS NIH HHS · R01 GM063364-08 · United States
NIDCD NIH HHS · R01 DC002174 · United States
NIDCD NIH HHS · R01 DC004729 · United States
NIDCD NIH HHS · R01 DC002174-24 · United States
NIGMS NIH HHS · R01 GM063364-07 · United States
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