Home LiteratureArticle Details
PMID: 20369064 Published · ppublish English Journal Article

Angiogenesis and lymphangiogenesis of gastric cancer.

Journal of oncology ·Vol. 2010 ·2010-00-00 ·Pages 468725

Kitadai Y

Abstract

Tumor angiogenesis is the result of an imbalance between positive and negative angiogenic factors released by tumor and host cells into the microenvironment of the neoplastic tissue. The stroma constitutes a large part of most solid tumors, and cancer-stromal cell interactions contribute functionally to tumor growth and metastasis. Activated fibroblasts and macrophages in tumor stroma play important roles in angiogenesis and tumor progression. In gastric cancer, tumor cells and stromal cells produce various angiogenic factors, including vascular endothelial growth factor, interleukin-8, platelet-derived endothelial cell growth factor, and angiopoietin. In addition, Helicobacter pylori infection increases tumor cell expression of metastasis-related genes including those encoding several angiogenic factors. We review the current understanding of molecular mechanisms involved in angiogenesis and lymphangiogenesis of human gastric cancer.

Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Kitadai Yasuhiko
Department of Medicine and Molecular Science, Hiroshima University Graduate School of Biomedical Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan.
References (94)
94 references, click to expand
  1. Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma.
    N Engl J Med. 1991 Jan 3;324(1):1-8 PMID: 1701519
  2. Expression of vascular endothelial growth factor and its receptor, KDR, correlates with vascularity, metastasis, and proliferation of human colon cancer.
    Cancer Res. 1995 Sep 15;55(18):3964-8 PMID: 7664263
  3. Role of C-X-C chemokines as regulators of angiogenesis in lung cancer.
    J Leukoc Biol. 1995 May;57(5):752-62 PMID: 7539029
  4. Induction of haptotactic migration of melanoma cells by neutrophil activating protein/interleukin-8.
    Biochem Biophys Res Commun. 1990 May 31;169(1):165-70 PMID: 2190552
  5. Monocyte chemoattractant protein-1 expression correlates with macrophage infiltration and tumor vascularity in human esophageal squamous cell carcinomas.
    Int J Cancer. 2002 Nov 20;102(3):220-4 PMID: 12397639
  6. Helicobacter pylori infection influences expression of genes related to angiogenesis and invasion in human gastric carcinoma cells.
    Biochem Biophys Res Commun. 2003 Nov 28;311(4):809-14 PMID: 14623253
  7. Helicobacter pylori promote gastric cancer cells invasion through a NF-kappaB and COX-2-mediated pathway.
    World J Gastroenterol. 2005 Jun 7;11(21):3197-203 PMID: 15929167
  8. Helicobacter pylori infection influences tumor growth of human gastric carcinomas.
    Scand J Gastroenterol. 2003 Feb;38(2):153-8 PMID: 12678331
  9. Prognostic value of vascular endothelial growth factor expression in gastric carcinoma.
    Cancer. 1996 Mar 1;77(5):858-63 PMID: 8608475
  10. Regulation of disease-progression genes in human gastric carcinoma cells by interleukin 8.
    Clin Cancer Res. 2000 Jul;6(7):2735-40 PMID: 10914718
  11. Correlation of metastasis-related gene expression with metastatic potential in human prostate carcinoma cells implanted in nude mice using an in situ messenger RNA hybridization technique.
    Am J Pathol. 1997 May;150(5):1571-82 PMID: 9137084
  12. Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion.
    Cell. 2005 May 6;121(3):335-48 PMID: 15882617
  13. Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis.
    Nat Med. 2001 Feb;7(2):192-8 PMID: 11175850
  14. Development of Helicobacter pylori-induced gastric carcinoma in Mongolian gerbils.
    Cancer Res. 1998 Oct 1;58(19):4255-9 PMID: 9766647
  15. Expression of interleukin-8 correlates with vascularity in human gastric carcinomas.
    Am J Pathol. 1998 Jan;152(1):93-100 PMID: 9422527
  16. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer.
    N Engl J Med. 2004 Jun 3;350(23):2335-42 PMID: 15175435
  17. Constitutive production of multiple cytokines and a human chorionic gonadotrophin beta-subunit by a human bladder cancer cell line (KU-19-19): possible demonstration of totipotential differentiation.
    Br J Cancer. 1997;76(2):163-74 PMID: 9231915
  18. Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in adenocarcinomas of the gastrointestinal tract.
    Cancer Res. 1993 Oct 1;53(19):4727-35 PMID: 8402650
  19. Cyclooxygenase-2 expression is related to prostaglandin biosynthesis and angiogenesis in human gastric cancer.
    Clin Cancer Res. 2000 Jan;6(1):135-8 PMID: 10656441
  20. Controlled recruitment of monocytes and macrophages to specific organs through transgenic expression of monocyte chemoattractant protein-1.
    J Immunol. 1995 Dec 15;155(12):5769-76 PMID: 7499865
  21. Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis.
    Science. 1997 Jul 4;277(5322):55-60 PMID: 9204896
  22. The significance of circulating vascular endothelial growth factor (VEGF) protein in gastric cancer.
    Cancer Lett. 2003 Mar 31;192(2):215-25 PMID: 12668286
  23. The expression of thymidine phosphorylase correlates with angiogenesis and the efficacy of chemotherapy using fluorouracil derivatives in advanced gastric carcinoma.
    Br J Cancer. 1999 Oct;81(3):484-9 PMID: 10507774
  24. Association of ovarian malignancy with expression of platelet-derived endothelial cell growth factor.
    J Natl Cancer Inst. 1994 Aug 17;86(16):1234-8 PMID: 7518876
  25. Molecular characterization of the tumor microenvironment in breast cancer.
    Cancer Cell. 2004 Jul;6(1):17-32 PMID: 15261139
  26. Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing.
    N Engl J Med. 1986 Dec 25;315(26):1650-9 PMID: 3537791
  27. Lymphoma-specific genetic aberrations in microvascular endothelial cells in B-cell lymphomas.
    N Engl J Med. 2004 Jul 15;351(3):250-9 PMID: 15254283
  28. Concomitant over-expression of vascular endothelial growth factor and its receptors in pancreatic cancer.
    Int J Cancer. 2000 Jan 1;85(1):27-34 PMID: 10585578
  29. Intratumoral heterogeneity for expression of tyrosine kinase growth factor receptors in human colon cancer surgical specimens and orthotopic tumors.
    Am J Pathol. 2008 Feb;172(2):358-66 PMID: 18202197
  30. What is the evidence that tumors are angiogenesis dependent?
    J Natl Cancer Inst. 1990 Jan 3;82(1):4-6 PMID: 1688381
  31. Macrophages, wound repair and angiogenesis.
    Prog Clin Biol Res. 1988;266:131-45 PMID: 2454496
  32. Antisense angiopoietin-1 inhibits tumorigenesis and angiogenesis of gastric cancer.
    World J Gastroenterol. 2006 Apr 21;12(15):2450-4 PMID: 16688843
  33. Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation.
    Nature. 1995 Jul 6;376(6535):70-4 PMID: 7596437
  34. The tumor microenvironment and its role in promoting tumor growth.
    Oncogene. 2008 Oct 6;27(45):5904-12 PMID: 18836471
  35. De novo expression of vascular endothelial growth factor in human pancreatic cancer: evidence for an autocrine mitogenic loop.
    Gastroenterology. 2000 Nov;119(5):1358-72 PMID: 11054395
  36. Monocyte chemoattractant protein-1 transfection induces angiogenesis and tumorigenesis of gastric carcinoma in nude mice via macrophage recruitment.
    Clin Cancer Res. 2005 Nov 1;11(21):7629-36 PMID: 16278381
  37. Macrophages: obligate partners for tumor cell migration, invasion, and metastasis.
    Cell. 2006 Jan 27;124(2):263-6 PMID: 16439202
  38. Anti-angiogenic therapy against gastrointestinal tract cancers.
    Jpn J Clin Oncol. 2009 Sep;39(9):543-51 PMID: 19531544
  39. Interleukin-8 expression in Helicobacter pylori infected, normal, and neoplastic gastroduodenal mucosa.
    J Clin Pathol. 1994 Jan;47(1):61-6 PMID: 8132812
  40. Helicobacter pylori infection induces gastric cancer in mongolian gerbils.
    Gastroenterology. 1998 Sep;115(3):642-8 PMID: 9721161
  41. Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid.
    Science. 1983 Feb 25;219(4587):983-5 PMID: 6823562
  42. Platelet-derived endothelial cell growth factor in human colon cancer angiogenesis: role of infiltrating cells.
    J Natl Cancer Inst. 1996 Aug 21;88(16):1146-51 PMID: 8757194
  43. The role of circulating IL-8 and VEGF protein in the progression of gastric cancer.
    Cancer Sci. 2003 Aug;94(8):735-40 PMID: 12901801
  44. Expression of interleukin 8 correlates with the metastatic potential of human melanoma cells in nude mice.
    Cancer Res. 1994 Jun 15;54(12):3242-7 PMID: 8205546
  45. Tumor-associated macrophage (TAM) infiltration in gastric cancer.
    Anticancer Res. 2003 Sep-Oct;23(5A):4079-83 PMID: 14666722
  46. Cyclooxygenase-2 overexpression correlates with vascular endothelial growth factor expression and tumor angiogenesis in gastric cancer.
    J Clin Gastroenterol. 2003 Jul;37(1):28-33 PMID: 12811205
  47. Patterns of metastases in intestinal and diffuse types of carcinoma of the stomach.
    Hum Pathol. 1981 Mar;12(3):237-42 PMID: 7228019
  48. Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor.
    Nature. 1989 Apr 13;338(6216):557-62 PMID: 2467210
  49. Critical factors in the biology of human cancer metastasis: twenty-eighth G.H.A. Clowes memorial award lecture.
    Cancer Res. 1990 Oct 1;50(19):6130-8 PMID: 1698118
  50. Expression of Tie-1 and 2 receptors, and angiopoietin-1, 2 and 4 in gastric carcinoma; immunohistochemical analyses and correlation with clinicopathological factors.
    Histopathology. 2004 Mar;44(3):232-9 PMID: 14987226
  51. Role of vascular endothelial growth factor C expression in the development of lymph node metastasis in gastric cancer.
    Clin Cancer Res. 1999 Jul;5(7):1823-9 PMID: 10430087
  52. Angiogenesis in normal and psoriatic skin.
    Lab Invest. 1989 Aug;61(2):139-42 PMID: 2474088
  53. Distinct role of macrophages in different tumor microenvironments.
    Cancer Res. 2006 Jan 15;66(2):605-12 PMID: 16423985
  54. Interleukin 8 and vascular endothelial growth factor -- prognostic factors in human gastric carcinomas?
    Eur J Cancer. 2001 Aug;37(12):1482-7 PMID: 11506954
  55. Cancer-related inflammation.
    Nature. 2008 Jul 24;454(7203):436-44 PMID: 18650914
  56. Expression of platelet-derived endothelial cell growth factor in Escherichia coli and confirmation of its thymidine phosphorylase activity.
    Biochemistry. 1992 Dec 8;31(48):12141-6 PMID: 1457409
  57. Extent of tumor vascularization correlates with prognosis and hematogenous metastasis in gastric carcinomas.
    Cancer Res. 1996 Jun 1;56(11):2671-6 PMID: 8653715
  58. Expression of activated platelet-derived growth factor receptor in stromal cells of human colon carcinomas is associated with metastatic potential.
    Int J Cancer. 2006 Dec 1;119(11):2567-74 PMID: 16988946
  59. Vascular endothelial growth factor family of ligands and receptors: review.
    Blood Cells Mol Dis. 2007 May-Jun;38(3):258-68 PMID: 17344076
  60. Monocyte chemoattractant protein-1 expression correlates with macrophage infiltration and tumor vascularity in human gastric carcinomas.
    Int J Oncol. 2003 Apr;22(4):773-8 PMID: 12632067
  61. Global cancer statistics, 2002.
    CA Cancer J Clin. 2005 Mar-Apr;55(2):74-108 PMID: 15761078
  62. Vascular-specific growth factors and blood vessel formation.
    Nature. 2000 Sep 14;407(6801):242-8 PMID: 11001067
  63. Significance of platelet-derived endothelial cell growth factor in the angiogenesis of human gastric cancer.
    Clin Cancer Res. 1998 Feb;4(2):429-34 PMID: 9516932
  64. Expression of growth factors, growth inhibiting factors, and their receptors in invasive breast cancer. I: An inventory in search of autocrine and paracrine loops.
    J Pathol. 1998 Jan;184(1):44-52 PMID: 9582526
  65. Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development.
    Proc Natl Acad Sci U S A. 1995 Apr 11;92(8):3566-70 PMID: 7724599
  66. Intracellular, intercellular, and stromal invasion of gastric mucosa, preneoplastic lesions, and cancer by Helicobacter pylori.
    Gastroenterology. 2007 Mar;132(3):1009-23 PMID: 17383424
  67. Expression of basic fibroblast growth factor in human gastric carcinomas.
    Virchows Arch B Cell Pathol Incl Mol Pathol. 1991;61(4):263-7 PMID: 1685819
  68. Expression of vascular endothelial growth factor in human gastric carcinomas.
    Pathol Int. 1998 Jul;48(7):499-506 PMID: 9701011
  69. Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by Angiopoietin-1.
    Dev Cell. 2002 Sep;3(3):411-23 PMID: 12361603
  70. Significance of vessel count and vascular endothelial growth factor and its receptor (KDR) in intestinal-type gastric cancer.
    Clin Cancer Res. 1996 Oct;2(10):1679-84 PMID: 9816116
  71. Blockade of vascular endothelial growth factor receptor-3 signaling inhibits fibroblast growth factor-2-induced lymphangiogenesis in mouse cornea.
    Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8868-73 PMID: 12070340
  72. Transfection of interleukin-8 increases angiogenesis and tumorigenesis of human gastric carcinoma cells in nude mice.
    Br J Cancer. 1999 Oct;81(4):647-53 PMID: 10574250
  73. Activation of IL-8 gene expression by Helicobacter pylori is regulated by transcription factor nuclear factor-kappa B in gastric epithelial cells.
    J Immunol. 1998 Mar 1;160(5):2401-7 PMID: 9498783
  74. Inhibition of interleukin 8 attenuates angiogenesis in bronchogenic carcinoma.
    J Exp Med. 1994 May 1;179(5):1409-15 PMID: 7513008
  75. Tumor induction of VEGF promoter activity in stromal cells.
    Cell. 1998 Sep 18;94(6):715-25 PMID: 9753319
  76. Expression of vascular endothelial growth factor (VEGF)-C and VEGF-D in early gastric carcinoma: correlation with clinicopathological parameters.
    Cancer Lett. 2005 Aug 8;226(1):85-90 PMID: 16004935
  77. Vascular endothelial growth factor C stimulates progression of human gastric cancer via both autocrine and paracrine mechanisms.
    Clin Cancer Res. 2008 Nov 15;14(22):7205-14 PMID: 19010837
  78. Pattern of adhesion molecule expression on vascular endothelium in Helicobacter pylori-associated antral gastritis.
    Gastroenterology. 1997 Jun;112(6):1908-19 PMID: 9178683
  79. Expressions and clinical significances of angiopoietin-1, -2 and Tie2 in human gastric cancer.
    Biochem Biophys Res Commun. 2005 Nov 11;337(1):386-93 PMID: 16185665
  80. Schistosomes, liver flukes and Helicobacter pylori. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Lyon, 7-14 June 1994.
    IARC Monogr Eval Carcinog Risks Hum. 1994;61:1-241 PMID: 7715068
  81. Vascular endothelial growth factor and platelet-derived endothelial cell growth factor are frequently coexpressed in highly vascularized human breast cancer.
    Clin Cancer Res. 1995 Sep;1(9):961-4 PMID: 9816067
  82. Angiopoietin-2 is related to tumor angiogenesis in gastric carcinoma: possible in vivo regulation via induction of proteases.
    Cancer Res. 2001 Mar 1;61(5):2145-53 PMID: 11280779
  83. PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasis.
    Cancer Cell. 2004 Oct;6(4):333-45 PMID: 15488757
  84. How is blood vessel growth regulated in normal and neoplastic tissue? G.H.A. Clowes memorial Award lecture.
    Cancer Res. 1986 Feb;46(2):467-73 PMID: 2416426
  85. Chemotherapy for metastatic gastric cancer: past, present, and future.
    J Gastroenterol. 2008;43(4):256-64 PMID: 18458840
  86. Role of tissue stroma in cancer cell invasion.
    J Pathol. 2003 Jul;200(4):429-47 PMID: 12845611
  87. Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning.
    Cell. 1996 Dec 27;87(7):1161-9 PMID: 8980223
  88. Targeting the expression of platelet-derived growth factor receptor by reactive stroma inhibits growth and metastasis of human colon carcinoma.
    Am J Pathol. 2006 Dec;169(6):2054-65 PMID: 17148668
  89. Significance of vessel count and vascular endothelial growth factor in human esophageal carcinomas.
    Clin Cancer Res. 1998 Sep;4(9):2195-200 PMID: 9748139
  90. Vascular endothelial growth factor (VEGF) expression in prostatic tumours and its relationship to neuroendocrine cells.
    Br J Cancer. 1996 Sep;74(6):910-6 PMID: 8826857
  91. Thymidine phosphorylase/platelet-derived endothelial cell growth factor expression associated with hepatic metastasis in gastric carcinoma.
    Br J Cancer. 1996 Apr;73(8):884-8 PMID: 8611421
  92. Stimulation of neovascularization by human rheumatoid synovial tissue macrophages.
    Arthritis Rheum. 1986 Apr;29(4):471-9 PMID: 2423091
  93. Cellular and molecular aspects of gastric cancer.
    World J Gastroenterol. 2006 May 21;12(19):2979-90 PMID: 16718776
  94. Vascular endothelial growth factor-C expression predicts lymph node metastasis of human gastric carcinomas invading the submucosa.
    Eur J Cancer. 2002 Jul;38(10):1413-9 PMID: 12091074
Article Info
Journal
Journal of oncology
Abbr.
J Oncol
ISSN
1687-8469
DOI
10.1155/2010/468725
Published
2010-00-00
Epub
2010-00-29
Pages
468725
Language
English
Region
Egypt
NLM ID
101496537
PMCID
PMC2847386
External Links
PubMed source DOI: 10.1155/2010/468725 PMC Full Text
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2