Vascular-specific growth factors and blood vessel formation.

Nature ·Vol. 407 ·No. 6801 ·2000-09-14 ·Pages 242-8

Yancopoulos GD, Davis S, Gale NW, Rudge JS, Wiegand SJ, Holash J

Abstract

A recent explosion in newly discovered vascular growth factors has coincided with exploitation of powerful new genetic approaches for studying vascular development. An emerging rule is that all of these factors must be used in perfect harmony to form functional vessels. These new findings also demand re-evaluation of therapeutic efforts aimed at regulating blood vessel growth in ischaemia, cancer and other pathological settings.

MeSH Terms

Angiopoietin-2 Animals Endothelial Growth Factors/genetics,physiology Ephrin-B2 Lymphokines/genetics,physiology Membrane Proteins/metabolism Models, Biological Neovascularization, Pathologic Neovascularization, Physiologic/drug effects Proteins/physiology Receptor Protein-Tyrosine Kinases/antagonists & inhibitors,physiology Receptors, Growth Factor/physiology Receptors, TIE Receptors, Vascular Endothelial Growth Factor Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors

Chemicals

Angiopoietin-2 Endothelial Growth Factors Ephrin-B2 Lymphokines Membrane Proteins Proteins Receptors, Growth Factor Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors Receptor Protein-Tyrosine Kinases Receptors, TIE Receptors, Vascular Endothelial Growth Factor

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Yancopoulos G D

Regeneron Pharmacueticals, Inc., Tarrytown, New York 10591, USA.

Davis S

Gale N W

Rudge J S

Wiegand S J

Holash J

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/35025215

Published

2000-09-14

Pages

242-8

Language

English

Region

England

NLM ID

0410462

Subset

External Links

PubMed source DOI: 10.1038/35025215 View journal details

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